Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 1304117..1304705 Replicon chromosome
Accession NZ_CP055302
Organism Mannheimia pernigra strain 16CN0041

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV561_RS06660 Protein ID WP_176808269.1
Coordinates 1304117..1304413 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HV561_RS06665 Protein ID WP_176808270.1
Coordinates 1304415..1304705 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV561_RS06610 1299223..1299837 - 615 WP_176808224.1 KilA-N domain-containing protein -
HV561_RS06615 1300134..1300460 - 327 WP_176808225.1 hypothetical protein -
HV561_RS06620 1300453..1300866 - 414 WP_176808226.1 hypothetical protein -
HV561_RS06625 1300875..1301813 - 939 WP_176808227.1 hypothetical protein -
HV561_RS06630 1301816..1301992 - 177 WP_176807314.1 hypothetical protein -
HV561_RS06635 1302000..1302140 - 141 WP_176808228.1 hypothetical protein -
HV561_RS06640 1302133..1302498 - 366 WP_176808229.1 helix-turn-helix domain-containing protein -
HV561_RS06645 1302495..1302638 - 144 WP_176807315.1 hypothetical protein -
HV561_RS06650 1303350..1303586 - 237 WP_176808267.1 hypothetical protein -
HV561_RS06655 1303583..1303801 - 219 WP_176808268.1 hypothetical protein -
HV561_RS06660 1304117..1304413 + 297 WP_176808269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV561_RS06665 1304415..1304705 + 291 WP_176808270.1 putative addiction module antidote protein Antitoxin
HV561_RS06670 1304795..1305277 - 483 Protein_1266 helix-turn-helix domain-containing protein -
HV561_RS06675 1305302..1305787 - 486 WP_176809011.1 hypothetical protein -
HV561_RS06680 1305792..1306172 - 381 WP_176808271.1 hypothetical protein -
HV561_RS06685 1306186..1306872 - 687 WP_176808272.1 S24 family peptidase -
HV561_RS06690 1307001..1307234 + 234 WP_032848913.1 antirepressor protein Cro -
HV561_RS06695 1307303..1308238 + 936 Protein_1271 DNA helicase -
HV561_RS06700 1308245..1308703 + 459 Protein_1272 replication protein -
HV561_RS06705 1308700..1309272 + 573 WP_176808230.1 adenine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1304780..1305277 497
- inside Prophage - - 1235768..1361333 125565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10973.83 Da        Isoelectric Point: 10.4759

>T162315 WP_176808269.1 NZ_CP055302:1304117-1304413 [Mannheimia pernigra]
MIQIKSTTVFRQWLDDLKDLRARAKIQTRIKRLQLGNFGDVKAVGEGISELRITEGKGYRVYLKNQNGVIVILLCGGDKS
TQENDIKTAKALVKELGV

Download         Length: 297 bp

>T162315 NZ_CP071731:c813519-813154 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10727.32 Da        Isoelectric Point: 4.8550

>AT162315 WP_176808270.1 NZ_CP055302:1304415-1304705 [Mannheimia pernigra]
MVELQDFDMAEHLRSEEEIQLYLNEVLKEADVDLILSALGDIAKARNMSQLAREVGVSREGLYKAFSGKGNPTFSTVLKV
MKALNLTFEVKQSVHA

Download         Length: 291 bp

>AT162315 NZ_CP071731:c813161-812838 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAACTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References