Detailed information of TA system TA162314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1277038..1277688
• Replicon: chromosome
• Accession: NZ_CP055302
• Organism: Mannheimia pernigra strain 16CN0041

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7H8UVF2
• Locus tag: HV561_RS06480
• Protein ID: WP_016527644.1
• Coordinates: 1277512..1277688 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HV561_RS06475
• Protein ID: WP_176808256.1
• Coordinates: 1277038..1277454 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV561_RS06435	1273383..1273817	+	435	WP_176808248.1	hypothetical protein	-
HV561_RS06440	1273829..1274818	+	990	WP_176808249.1	encapsulin	-
HV561_RS06445	1274830..1275036	+	207	WP_176808250.1	hypothetical protein	-
HV561_RS06450	1275039..1275416	+	378	WP_176808251.1	hypothetical protein	-
HV561_RS06455	1275416..1275763	+	348	WP_176808252.1	hypothetical protein	-
HV561_RS06460	1275763..1276131	+	369	WP_176808253.1	HK97 gp10 family phage protein	-
HV561_RS06465	1276128..1276502	+	375	WP_176808254.1	hypothetical protein	-
HV561_RS06470	1276514..1276993	+	480	WP_176808255.1	phage tail protein	-
HV561_RS06475	1277038..1277454	-	417	WP_176808256.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV561_RS06480	1277512..1277688	-	177	WP_016527644.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV561_RS06485	1277785..1278450	+	666	WP_176808257.1	hypothetical protein	-
HV561_RS06490	1278465..1278698	-	234	WP_176808258.1	hypothetical protein	-
HV561_RS06495	1278867..1279325	+	459	WP_176808259.1	hypothetical protein	-
HV561_RS06500	1279560..1282055	+	2496	WP_176808260.1	phage tail length tape measure family protein	-
HV561_RS06505	1282060..1282389	+	330	WP_176808261.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1235768..1361333	125565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6640.74 Da
• Isoelectric Point: 10.6914

>T162314 WP_016527644.1 NZ_CP055302:c1277688-1277512 [Mannheimia pernigra]
VKQSEFLRWLKANGVEVENGTKHLKLYYNGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Nucleotide

• Length: 177 bp

>T162314 NZ_CP071731:c595781-595026 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15634.01 Da
• Isoelectric Point: 4.5304

>AT162314 WP_176808256.1 NZ_CP055302:c1277454-1277038 [Mannheimia pernigra]
MFYPALFTPAEEGGFVVTFPDIPEALTQGDTFEEAMEMAEDVLISSVEIYFDDERVFPLSRPTGIYETSVFMPESVYAKI
LLHNTMCEKFISKAEVSRLNNIKPPEIHRILNPRHTTRIDTIGRILVSLGRPLQLSLA

Nucleotide

• Length: 417 bp

>AT162314 NZ_CP071731:c596284-595916 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCACCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A7H8UVF2