Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1263569..1264232 Replicon chromosome
Accession NZ_CP055302
Organism Mannheimia pernigra strain 16CN0041

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HV561_RS06355 Protein ID WP_176808235.1
Coordinates 1264050..1264232 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV561_RS06350 Protein ID WP_176808234.1
Coordinates 1263569..1264021 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV561_RS06315 1258873..1259043 + 171 WP_006250083.1 hypothetical protein -
HV561_RS06320 1259018..1259887 + 870 WP_006250084.1 replication protein -
HV561_RS06325 1259884..1261245 + 1362 WP_006250085.1 replicative DNA helicase -
HV561_RS06330 1261242..1261814 + 573 WP_176808230.1 adenine methyltransferase -
HV561_RS06335 1261933..1262385 + 453 WP_176808231.1 DUF1367 family protein -
HV561_RS06340 1262394..1262594 + 201 WP_176808232.1 hypothetical protein -
HV561_RS06345 1262643..1263311 - 669 WP_176808233.1 hypothetical protein -
HV561_RS06350 1263569..1264021 - 453 WP_176808234.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV561_RS06355 1264050..1264232 - 183 WP_176808235.1 type II toxin-antitoxin system HicA family toxin Toxin
HV561_RS06360 1264353..1264922 + 570 WP_176808236.1 recombination protein NinG -
HV561_RS06365 1264912..1265385 + 474 WP_176808237.1 hypothetical protein -
HV561_RS06380 1265672..1266247 - 576 WP_176808238.1 hypothetical protein -
HV561_RS06385 1266360..1266605 + 246 WP_176808239.1 hypothetical protein -
HV561_RS06390 1266602..1267141 + 540 WP_176808240.1 lysozyme -
HV561_RS06395 1267114..1267464 + 351 WP_176808241.1 DUF2570 domain-containing protein -
HV561_RS06400 1267469..1267642 + 174 WP_176808242.1 hypothetical protein -
HV561_RS06410 1268043..1268567 + 525 WP_176808244.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1235768..1361333 125565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(12-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6728.94 Da        Isoelectric Point: 10.4193

>T162313 WP_176808235.1 NZ_CP055302:c1264232-1264050 [Mannheimia pernigra]
MHSRDLIKELKAHGCYLKRMGKGDHQIWYSPITGKTFPVPHPKEDLAIGTLKSIKKSAGL

Download         Length: 183 bp

>T162313 NZ_CP071730:6253191-6253769 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 17113.38 Da        Isoelectric Point: 4.5217

>AT162313 WP_176808234.1 NZ_CP055302:c1264021-1263569 [Mannheimia pernigra]
MIFTVGLEIPEDTETTAYGMIVPALCEHNYGCFSAADEVEELLPMVTEAIQLNLESMAEDGFDLTTLKDKGIPHYKNDPE
YAHFKDWFLVDVDISPYLGSKQRINITMPEFLLNRIDRRVAAMGNFYKDRSHFLATAAHRELHAHSNTEM

Download         Length: 453 bp

>AT162313 NZ_CP071730:6252548-6253102 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References