Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 188197..188828 Replicon chromosome
Accession NZ_CP055302
Organism Mannheimia pernigra strain 16CN0041

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV561_RS00890 Protein ID WP_176807449.1
Coordinates 188197..188595 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV561_RS00895 Protein ID WP_176807450.1
Coordinates 188595..188828 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV561_RS00870 185030..185296 - 267 WP_176807446.1 chaperone NapD -
HV561_RS00875 185313..185837 - 525 WP_176808965.1 ferredoxin-type protein NapF -
HV561_RS00880 186006..186581 + 576 WP_176807447.1 NAD(P)H-dependent oxidoreductase -
HV561_RS00885 186642..188177 - 1536 WP_176807448.1 L-2,4-diaminobutyrate decarboxylase -
HV561_RS00890 188197..188595 - 399 WP_176807449.1 tRNA(fMet)-specific endonuclease VapC Toxin
HV561_RS00895 188595..188828 - 234 WP_176807450.1 antitoxin Antitoxin
HV561_RS00900 188997..190361 - 1365 WP_176807451.1 diaminobutyrate--2-oxoglutarate transaminase -
HV561_RS00905 190709..190879 - 171 WP_159628615.1 50S ribosomal protein L33 -
HV561_RS00910 190883..191128 - 246 WP_176807452.1 50S ribosomal protein L28 -
HV561_RS00915 191299..191991 - 693 WP_176807453.1 DNA repair protein RadC -
HV561_RS00920 192149..193351 + 1203 WP_176807454.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14891.17 Da        Isoelectric Point: 8.0586

>T162312 WP_176807449.1 NZ_CP055302:c188595-188197 [Mannheimia pernigra]
MLKYMLDSNIVIYVIKHRPVEVLQRFNQNAGKMCVSSITAAELYYGAEKSGFSARNIAVIEDFLSRLTILDYQPKSAAHF
GNIKAELAKQGKLIGENDIHIAAHARSEGLVIVTNNLREFERVEGLRLENWV

Download         Length: 399 bp

>T162312 NZ_CP071730:4506485-4507072 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGAGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9009.22 Da        Isoelectric Point: 4.3094

>AT162312 WP_176807450.1 NZ_CP055302:c188828-188595 [Mannheimia pernigra]
MIEASIFMTNRSQAVRLPAEVRFDNDVKKIAVRILGNERILSPLNQSWDSFFLNSETVSEDFMVEREIAMQPEREDF

Download         Length: 234 bp

>AT162312 NZ_CP071730:4507139-4507993 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGTGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References