Detailed information of TA system TA162311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 154498..155017
• Replicon: chromosome
• Accession: NZ_CP055302
• Organism: Mannheimia pernigra strain 16CN0041

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV561_RS00760
• Protein ID: WP_176807429.1
• Coordinates: 154498..154764 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: HV561_RS00765
• Protein ID: WP_159628595.1
• Coordinates: 154751..155017 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV561_RS00740	149967..150401	-	435	WP_176807425.1	D-tyrosyl-tRNA(Tyr) deacylase	-
HV561_RS00745	150376..151221	-	846	WP_176807426.1	virulence factor BrkB family protein	-
HV561_RS00750	151223..152461	-	1239	WP_176807427.1	glutamate-5-semialdehyde dehydrogenase	-
HV561_RS00755	152581..154473	+	1893	WP_176807428.1	DNA mismatch repair endonuclease MutL	-
HV561_RS00760	154498..154764	-	267	WP_176807429.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HV561_RS00765	154751..155017	-	267	WP_159628595.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV561_RS00770	155181..156134	+	954	WP_176808964.1	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	-
HV561_RS00775	156205..156480	+	276	WP_159628596.1	RNA chaperone Hfq	-
HV561_RS00780	156501..157895	+	1395	WP_176807430.1	GTPase HflX	-
HV561_RS00785	158170..159339	-	1170	WP_176807431.1	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10309.87 Da
• Isoelectric Point: 6.7013

>T162311 WP_176807429.1 NZ_CP055302:c154764-154498 [Mannheimia pernigra]
MREIEYSNAFKRDYKKCAVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG

Nucleotide

• Length: 267 bp

>T162311 NZ_CP071730:c2764535-2764254 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9704.13 Da
• Isoelectric Point: 4.7863

>AT162311 WP_159628595.1 NZ_CP055302:c155017-154751 [Mannheimia pernigra]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD

Nucleotide

• Length: 267 bp

>AT162311 NZ_CP071730:c2764759-2764532 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA