Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 154498..155017 Replicon chromosome
Accession NZ_CP055302
Organism Mannheimia pernigra strain 16CN0041

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HV561_RS00760 Protein ID WP_176807429.1
Coordinates 154498..154764 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag HV561_RS00765 Protein ID WP_159628595.1
Coordinates 154751..155017 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV561_RS00740 149967..150401 - 435 WP_176807425.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV561_RS00745 150376..151221 - 846 WP_176807426.1 virulence factor BrkB family protein -
HV561_RS00750 151223..152461 - 1239 WP_176807427.1 glutamate-5-semialdehyde dehydrogenase -
HV561_RS00755 152581..154473 + 1893 WP_176807428.1 DNA mismatch repair endonuclease MutL -
HV561_RS00760 154498..154764 - 267 WP_176807429.1 type II toxin-antitoxin system YafQ family toxin Toxin
HV561_RS00765 154751..155017 - 267 WP_159628595.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV561_RS00770 155181..156134 + 954 WP_176808964.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
HV561_RS00775 156205..156480 + 276 WP_159628596.1 RNA chaperone Hfq -
HV561_RS00780 156501..157895 + 1395 WP_176807430.1 GTPase HflX -
HV561_RS00785 158170..159339 - 1170 WP_176807431.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10309.87 Da        Isoelectric Point: 6.7013

>T162311 WP_176807429.1 NZ_CP055302:c154764-154498 [Mannheimia pernigra]
MREIEYSNAFKRDYKKCAVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG

Download         Length: 267 bp

>T162311 NZ_CP071730:c2764535-2764254 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9704.13 Da        Isoelectric Point: 4.7863

>AT162311 WP_159628595.1 NZ_CP055302:c155017-154751 [Mannheimia pernigra]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD

Download         Length: 267 bp

>AT162311 NZ_CP071730:c2764759-2764532 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References