Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5060402..5062083 | Replicon | chromosome |
| Accession | NZ_CP055294 | ||
| Organism | Klebsiella pneumoniae strain KP55 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | HUW33_RS25055 | Protein ID | WP_002885155.1 |
| Coordinates | 5060402..5061319 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | HUW33_RS25060 | Protein ID | WP_004151732.1 |
| Coordinates | 5061325..5062083 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUW33_RS25035 (HUW33_25025) | 5055708..5057228 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| HUW33_RS25040 (HUW33_25030) | 5057225..5058223 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| HUW33_RS25045 (HUW33_25035) | 5058254..5059195 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| HUW33_RS25050 (HUW33_25040) | 5059270..5060277 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| HUW33_RS25055 (HUW33_25045) | 5060402..5061319 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| HUW33_RS25060 (HUW33_25050) | 5061325..5062083 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| HUW33_RS25065 (HUW33_25055) | 5062169..5062897 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| HUW33_RS25070 (HUW33_25060) | 5063170..5065317 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| HUW33_RS25075 (HUW33_25065) | 5065547..5066233 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T162297 WP_002885155.1 NZ_CP055294:c5061319-5060402 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T162297 NZ_CP071717:1221569-1221823 [Acaryochloris sp. 'Moss Beach']
ATGAACATCATTTCCTTCAGTGAAGCCCGCAGCAAACTGAAAGCTGTCTTCGATCGAGTCGTTGATGATGCCGACTACAC
GATCATCACTCGACGAGATGCTGATGATGCAGTGTTGATGTCTCTGGAGTCTTTTAATAGCTTGCTAGAAACCGTTCATT
TGTTAAAGTCACCCGCCAATGCAGCTCACCTAGAACAATCCATTGCCCAATATCGACAGGGACAAGTGACTGAGCAAGAC
CTCTTGGATGAGTAG
ATGAACATCATTTCCTTCAGTGAAGCCCGCAGCAAACTGAAAGCTGTCTTCGATCGAGTCGTTGATGATGCCGACTACAC
GATCATCACTCGACGAGATGCTGATGATGCAGTGTTGATGTCTCTGGAGTCTTTTAATAGCTTGCTAGAAACCGTTCATT
TGTTAAAGTCACCCGCCAATGCAGCTCACCTAGAACAATCCATTGCCCAATATCGACAGGGACAAGTGACTGAGCAAGAC
CTCTTGGATGAGTAG
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT162297 WP_004151732.1 NZ_CP055294:c5062083-5061325 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT162297 NZ_CP071717:1221816-1222079 [Acaryochloris sp. 'Moss Beach']
ATGAGTAGTCGCAAATTGGCCTGGACAGATGCTGCCTGGAACGACTATCTCTACTGGCAAGGACAGGATAAAAAAACGCT
GAAGCGGATCAATAAGCTCATTCAGGCTACGAACAATCAGCCATTTAAAGGCATTGGTAAACCTGAGGCTTTACGAGAAA
ATCTATCGGGATTTTGGTCTCGACGCATAGATGAGACCCATCGATTAGTCTATGCCATTGATGATCACTATCTGACAATT
ATTGCCTGTCGGTATCATTATTAG
ATGAGTAGTCGCAAATTGGCCTGGACAGATGCTGCCTGGAACGACTATCTCTACTGGCAAGGACAGGATAAAAAAACGCT
GAAGCGGATCAATAAGCTCATTCAGGCTACGAACAATCAGCCATTTAAAGGCATTGGTAAACCTGAGGCTTTACGAGAAA
ATCTATCGGGATTTTGGTCTCGACGCATAGATGAGACCCATCGATTAGTCTATGCCATTGATGATCACTATCTGACAATT
ATTGCCTGTCGGTATCATTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |