Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4903018..4903534 Replicon chromosome
Accession NZ_CP055294
Organism Klebsiella pneumoniae strain KP55

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUW33_RS24250 Protein ID WP_002886902.1
Coordinates 4903018..4903302 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUW33_RS24255 Protein ID WP_002886901.1
Coordinates 4903292..4903534 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW33_RS24225 (HUW33_24215) 4898502..4898765 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
HUW33_RS24230 (HUW33_24220) 4898895..4899068 + 174 WP_002886906.1 hypothetical protein -
HUW33_RS24235 (HUW33_24225) 4899071..4899814 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUW33_RS24240 (HUW33_24230) 4900171..4902309 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUW33_RS24245 (HUW33_24235) 4902550..4903014 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUW33_RS24250 (HUW33_24240) 4903018..4903302 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUW33_RS24255 (HUW33_24245) 4903292..4903534 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUW33_RS24260 (HUW33_24250) 4903612..4905522 - 1911 WP_004152270.1 PRD domain-containing protein -
HUW33_RS24265 (HUW33_24255) 4905545..4906699 - 1155 WP_002886900.1 lactonase family protein -
HUW33_RS24270 (HUW33_24260) 4906765..4907505 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T162296 WP_002886902.1 NZ_CP055294:c4903302-4903018 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T162296 NZ_CP071717:c760698-760267 [Acaryochloris sp. 'Moss Beach']
ATGTATTTGATTGATACTAACGTCATTAGTGAACTCCGCAAGCAGGCAAGAGCTGATCCGGGTGTACGGAAGTTTTTTCA
GGTTGCTGCTGAGCAAAAAGCTCGCTTATACATCAGTGCCATCACTATTGGAGAGTTACGTCGAGGGGTTGAACTGATTC
GCTATCGTGGTGATTTACCGCAAGCTAGCCTATTAGAGAATTGGTTGCAAACCATTTTAGACAGCTATGCTGACCATATT
CTCGATTTTACGGAAGTGGAAGCTCAGGTATGGGGATGTTTATGTGCTCCCCAACCCCAGAATGCGATCGATAAACAAAT
TGCTGCGATTGCCTTGACTCGTGACTTAATTTTGGTGACTCGTAATGTGAGTGATTTTGCTGATACAGGGGTATCTCTGG
TTAACCCTTTTGAGGTTGCTGATACTGTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT162296 WP_002886901.1 NZ_CP055294:c4903534-4903292 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT162296 NZ_CP071717:c760918-760685 [Acaryochloris sp. 'Moss Beach']
ATGGCAAATCTGATTGTTCGTAATATTGACGACTCTATAGTCAGAGCCTTAAAGATGCGGGCTAGTCAGAATGGCGTGAG
CGCTGAGGCCGAACATCGCAAAATCTTAGAACAGGTATTGTTTCATCCACCCCAGAAGTCCTTCTCTGAAGTTCTTTGCC
AAATTCCACAGGTTGGCTGTGACGAAGATTTTGAGCGAATCCAGGATGACTTAGCTCAAGATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References