Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 865185..865842 Replicon chromosome
Accession NZ_CP055293
Organism Klebsiella pneumoniae strain 200

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HWA76_RS04335 Protein ID WP_002916310.1
Coordinates 865432..865842 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HWA76_RS04330 Protein ID WP_002916312.1
Coordinates 865185..865451 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWA76_RS04305 (860341) 860341..861774 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HWA76_RS04310 (861893) 861893..862621 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HWA76_RS04315 (862671) 862671..862982 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HWA76_RS04320 (863146) 863146..863805 + 660 WP_002916317.1 hemolysin III family protein -
HWA76_RS04325 (863956) 863956..864939 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HWA76_RS04330 (865185) 865185..865451 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HWA76_RS04335 (865432) 865432..865842 + 411 WP_002916310.1 protein YgfX Toxin
HWA76_RS04340 (865849) 865849..866370 - 522 WP_002916308.1 flavodoxin FldB -
HWA76_RS04345 (866471) 866471..867367 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HWA76_RS04350 (867390) 867390..868103 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HWA76_RS04355 (868109) 868109..869842 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T162265 WP_002916310.1 NZ_CP055293:865432-865842 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T162265 NZ_CP071709:376046-376396 [Cytobacillus gottheilii]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCCGAACAAGGCGGCGTACGTCCAGT
ATTGGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTATTGCAGCAATAACGGCCCAGATCCAAAAAG
CAAAGCTGCCTACTCACGTTGAAATTGATGCGAAACGTTATGGGTTTGAAAGGGATTCAGTCATCCTCTTAGAACAGATT
CGTACAATTGATAAACAGCGCTTAACCGATAAGATTACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCCT
GCAAATTAGTTTAGGACTCATCGAATTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT162265 WP_002916312.1 NZ_CP055293:865185-865451 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162265 NZ_CP071709:375760-376041 [Cytobacillus gottheilii]
GTGTCTGAGTCCAGCACAACAACAGAGATTATGGTGGAGCTGCCGCAGCAGCTTTTGACCGAGTTAGACGGCTTTGTAAA
GCAGGAAAACGTTAATCGGAGTGAACTCATTTATCAAGCGACCAAAATGTATTTGCGTGAACGGAAAAAAAGACAGATTC
GCGAATCCATGAGACGCGGCTATATGGAAATGGCAAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAT
GAGGCAGAACACACAGTTGAACGTCTTGTAAGCGGAGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References