Detailed information of TA system TA162260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 4419109..4419747
• Replicon: chromosome
• Accession: NZ_CP055292
• Organism: Shigella sonnei strain SE6-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: HUX90_RS21060
• Protein ID: WP_000813794.1
• Coordinates: 4419571..4419747 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HUX90_RS21055
• Protein ID: WP_001270286.1
• Coordinates: 4419109..4419525 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUX90_RS21035	4414261..4415202	-	942	WP_001251319.1	ABC transporter permease	-
HUX90_RS21040	4415203..4416216	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
HUX90_RS21045	4416234..4417379	-	1146	WP_000047456.1	ABC transporter substrate-binding protein	-
HUX90_RS21050	4417624..4419030	-	1407	WP_000760629.1	PLP-dependent aminotransferase family protein	-
HUX90_RS21055	4419109..4419525	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HUX90_RS21060	4419571..4419747	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HUX90_RS21065	4419969..4420199	+	231	WP_000494244.1	YncJ family protein	-
HUX90_RS21070	4420291..4422252	-	1962	WP_001307191.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HUX90_RS21075	4422325..4422861	-	537	WP_000429141.1	DNA-binding transcriptional regulator SutR	-
HUX90_RS21080	4422914..4424128	+	1215	WP_001349372.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4424168..4425433	1265

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T162260 WP_000813794.1 NZ_CP055292:c4419747-4419571 [Shigella sonnei]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T162260 NZ_CP071698:c2094418-2094053 [Actinobacillus pleuropneumoniae]
ATAGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT162260 WP_001270286.1 NZ_CP055292:c4419525-4419109 [Shigella sonnei]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT162260 NZ_CP071698:c2094768-2094481 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Toxin

• PDB: 6HPB