Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4249480..4250006 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HUX90_RS20250 Protein ID WP_000323025.1
Coordinates 4249719..4250006 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HUX90_RS20245 Protein ID WP_000534858.1
Coordinates 4249480..4249719 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS20220 4244816..4245172 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
HUX90_RS20225 4245783..4246069 + 287 Protein_3931 hypothetical protein -
HUX90_RS20230 4246838..4248178 + 1341 WP_000589013.1 ISNCY family transposase -
HUX90_RS20235 4248615..4248947 - 333 WP_001301033.1 protein FlxA -
HUX90_RS20240 4249150..4249455 - 306 WP_071593935.1 hypothetical protein -
HUX90_RS20245 4249480..4249719 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HUX90_RS20250 4249719..4250006 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HUX90_RS20255 4250078..4250233 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HUX90_RS20260 4250450..4250701 + 252 WP_001463433.1 hypothetical protein -
HUX90_RS20265 4250768..4251046 + 279 WP_040091072.1 hypothetical protein -
HUX90_RS20270 4251048..4252097 + 1050 WP_016247238.1 DUF968 domain-containing protein -
HUX90_RS20275 4252111..4252863 + 753 WP_001047135.1 antitermination protein -
HUX90_RS20280 4253141..4253230 - 90 WP_120795389.1 hypothetical protein -
HUX90_RS20285 4253285..4253497 - 213 WP_000087756.1 cold shock-like protein CspF -
HUX90_RS20290 4253798..4254013 + 216 WP_000066484.1 cold shock-like protein CspB -
HUX90_RS20295 4254767..4254982 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4231792..4285321 53529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T162258 WP_000323025.1 NZ_CP055292:4249719-4250006 [Shigella sonnei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T162258 NZ_CP071698:c1794602-1794135 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT162258 WP_000534858.1 NZ_CP055292:4249480-4249719 [Shigella sonnei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT162258 NZ_CP071698:c1794866-1794606 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References