Detailed information of TA system TA162248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3327668..3328293
• Replicon: chromosome
• Accession: NZ_CP055292
• Organism: Shigella sonnei strain SE6-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUX90_RS15800
• Protein ID: WP_000911330.1
• Coordinates: 3327895..3328293 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U9XQV3
• Locus tag: HUX90_RS15795
• Protein ID: WP_000450524.1
• Coordinates: 3327668..3327895 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUX90_RS15770	3323472..3323942	-	471	WP_001068682.1	thioredoxin-dependent thiol peroxidase	-
HUX90_RS15775	3323942..3324514	-	573	WP_000176187.1	glycine cleavage system transcriptional repressor	-
HUX90_RS15780	3324660..3325538	+	879	WP_001295469.1	4-hydroxy-tetrahydrodipicolinate synthase	-
HUX90_RS15785	3325555..3326589	+	1035	WP_001297320.1	outer membrane protein assembly factor BamC	-
HUX90_RS15790	3326802..3327515	+	714	WP_001295467.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HUX90_RS15795	3327668..3327895	+	228	WP_000450524.1	toxin-antitoxin system antitoxin VapB	Antitoxin
HUX90_RS15800	3327895..3328293	+	399	WP_000911330.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HUX90_RS15805	3328440..3329303	+	864	WP_001267508.1	neutral zinc metallopeptidase	-
HUX90_RS15810	3329318..3331333	+	2016	WP_000829329.1	tRNA cytosine(34) acetyltransferase TmcA	-
HUX90_RS15815	3331407..3332105	+	699	WP_000679823.1	esterase	-
HUX90_RS15820	3332215..3332415	-	201	WP_000383836.1	YpfN family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14894.25 Da
• Isoelectric Point: 9.2216

>T162248 WP_000911330.1 NZ_CP055292:3327895-3328293 [Shigella sonnei]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Nucleotide

• Length: 399 bp

>T162248 NZ_CP071697:c1168474-1168217 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGTTGGATAAAACTGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATTGACGGGTGTGACAACCCCAGACAATACGGAAAAGCTTTGACTGCCAATCGTTCTGGCC
AATGGCGGTACCGTATTGGCAATTATCGGGTCATCGTCAGTATTGAAATCGACAAATTGATTTTGACAAGTCTAAAAATG
AGAAATGGAAGTATATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8498.61 Da
• Isoelectric Point: 4.3867

>AT162248 WP_000450524.1 NZ_CP055292:3327668-3327895 [Shigella sonnei]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Nucleotide

• Length: 228 bp

>AT162248 NZ_CP071697:c1168703-1168464 [Streptococcus suis]
ATGGCAGCTATTACTTTAAAGGTTTCTGAGCAGGACAAACTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCCCGTGTGGCAGACATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A829CM33