162247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3005078..3005661 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag HUX90_RS14250 Protein ID WP_000254745.1
Coordinates 3005326..3005661 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag HUX90_RS14245 Protein ID WP_000581937.1
Coordinates 3005078..3005326 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS14235 3001417..3002718 + 1302 WP_000046790.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
HUX90_RS14240 3002766..3005000 + 2235 WP_000226815.1 GTP pyrophosphokinase -
HUX90_RS14245 3005078..3005326 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HUX90_RS14250 3005326..3005661 + 336 WP_000254745.1 endoribonuclease MazF Toxin
HUX90_RS14255 3005732..3006523 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
HUX90_RS14260 3006751..3008388 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
HUX90_RS14265 3008476..3009774 + 1299 WP_000036723.1 phosphopyruvate hydratase -
HUX90_RS14270 3009830..3010192 - 363 WP_000034929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T162247 WP_000254745.1 NZ_CP055292:3005326-3005661 [Shigella sonnei]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T162247 NZ_CP071697:c918545-918354 [Streptococcus suis]
ATGCCACTTACTGGAAAAGAAATGGCAAAACTTGCAGAGGCTAACGGGTGGAAAGAAATCCGAGTCAATGGAAGTCACCA
CCATTTCAAAAAAGAAGGATTTTCAAAAATAGTCACAATCCCAGTTCATGGAAACAAGGACTTGGGCAAAGGGCTAGAAA
AGAAAATCCTGAGAGATTTGGGGCTACTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT162247 WP_000581937.1 NZ_CP055292:3005078-3005326 [Shigella sonnei]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT162247 NZ_CP071697:c918318-917941 [Streptococcus suis]
ATGTTAAAATCTTACCCAGCTATTTTTCATAAAGATGAACAAGGTTATTGGGTGGAGTTCCCAGAGTTTAGTGGTGGTAC
TCAAGGGGATAACCTTGAGGAAGCTATGTACAATGCCCGTGATTTTTTAGAAAGCTCTATTGCCCTTTATATTGATGAGG
GGATGGAGTTACCAAAAGTAAGCGATATAAAGGAGTTAAGCGCTCCTGATGGCTTTGTTTCAATGATACAAGCTGATCCA
ACACCGTATATTAAGAATAATAAAGCAATTAGAAAGAATGTGACAGTGCCTGAATGGTTAACAAAATTGGCAGACCGTGA
GGGTTTGAACTATTCGGAAATTTTAACAACGGCTTTAGAAACACGATTACAAGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References