Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2868809..2869463 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag HUX90_RS13640 Protein ID WP_000244772.1
Coordinates 2869056..2869463 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUX90_RS13635 Protein ID WP_000354046.1
Coordinates 2868809..2869075 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS13610 2864097..2864840 + 744 WP_000951964.1 SDR family oxidoreductase -
HUX90_RS13615 2864897..2866330 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
HUX90_RS13620 2866375..2866686 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
HUX90_RS13625 2866850..2867509 + 660 WP_000250274.1 hemolysin III family protein -
HUX90_RS13630 2867586..2868566 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HUX90_RS13635 2868809..2869075 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUX90_RS13640 2869056..2869463 + 408 WP_000244772.1 protein YgfX Toxin
HUX90_RS13645 2869503..2870024 - 522 WP_001055874.1 flavodoxin FldB -
HUX90_RS13650 2870136..2871032 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUX90_RS13655 2871057..2871767 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUX90_RS13660 2871773..2873506 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T162246 WP_000244772.1 NZ_CP055292:2869056-2869463 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T162246 NZ_CP071696:c2952375-2951956 [Agromyces archimandritae]
GTGATCATCCTCGACACCAACGTCATTTCCGAGGGCTTCCGCTCCCGGCCGGAGCCGTCCGTGATCGCCTGGATGGAAAC
CCTCGTCGACGAGGTCTCCATCACCGCGATCACCCTGGCCGAGCTCCTCGCGGGTGTACGGCGACTCCCCGAGGGGGCAC
GCAAGGCCGCTCTCACGGCGGGAATCGACACCGCCCTCGACGACTATCGGCAGAGCGCCGCGATCCTGGCGTTCGACGAC
CGGGCAGCCGAACGCTACGCGGACATCCTCACGATCCGCGAACGCGCCGGCCTGCCGATCAGCTCCGCCGACGCGCAGAT
CGCCGCGATCTGCCGGGTGCACGGCGCGACCCTCGCCACACGCAACACGAAGGACTTCGAGAAGACCGGCGTCGCGCTCG
TGAACCCGTGGAGCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT162246 WP_000354046.1 NZ_CP055292:2868809-2869075 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162246 NZ_CP071696:c2952605-2952372 [Agromyces archimandritae]
ATGGCATCCGTGATCGTCCGCGGACTCGACGAGTCGGTGAAAAGCAGGATCGCCGAGCAGGCGAAAGAGCACGGGCGGTC
GATGGAGGCGGAGATCCGTCACATCCTCACCCGCGCAGCGCATCGACCCCATATCGGCATTGCGCTCATGCGAGCTGCAC
AGGCAGCAGGCGGCGCCGACGACCTCGAGACCCCTGATCGCACCGACACAGCTCGAGCGGCGGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References