Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2295775..2296575 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag HUX90_RS10775 Protein ID WP_000342449.1
Coordinates 2296048..2296575 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag HUX90_RS10770 Protein ID WP_001277108.1
Coordinates 2295775..2296041 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS10750 2291433..2292101 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
HUX90_RS10755 2292094..2293152 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
HUX90_RS10760 2293397..2294251 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
HUX90_RS10765 2294522..2295625 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
HUX90_RS10770 2295775..2296041 + 267 WP_001277108.1 DUF1778 domain-containing protein Antitoxin
HUX90_RS10775 2296048..2296575 + 528 WP_000342449.1 GNAT family N-acetyltransferase Toxin
HUX90_RS10780 2296572..2296955 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
HUX90_RS10785 2297379..2298488 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
HUX90_RS10790 2298536..2299462 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HUX90_RS10795 2299459..2300736 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
HUX90_RS10800 2300733..2301500 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T162244 WP_000342449.1 NZ_CP055292:2296048-2296575 [Shigella sonnei]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T162244 NZ_CP071696:c1651330-1650953 [Agromyces archimandritae]
ATGAGCATCCTCGTCGACACCTCCGTGCTCATCGACGTGCTCCGGGGCATCCCCGAGGCGGCGGGCGTGCTGCGCGATGC
GCGGGCCGATGGGCCCCTGCACGCGAGCGAGATCACCCGACTCGAAGTGCTCGCCGGGATGCGCCCGCGCGAAGAGGCGG
CGACCCGCGAACTGCTCGACGTGCTGAACTGGCGCCCTGTGGACGACCGGATCGCCGAAGTCGCCGGCGAACTCGGCCGC
GCGTGGCTTCCCGGCAACCGCGGCATCGATTCCGCAGACCTCGCGATCGCCGCCACCGCCATCGTGCTCGATGCCCGGTT
GTTCACGCGGAACGTCAAGCACTTCCCGATGTTCCACGGCCTGACCGCCCCGTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT162244 WP_001277108.1 NZ_CP055292:2295775-2296041 [Shigella sonnei]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT162244 NZ_CP071696:c1651578-1651327 [Agromyces archimandritae]
ATGTTGCGCACGCAGATCTCGCTCACGGATGAGGACCGCGCCCTGCTCGACGCCGAGGCGGCCCGGACCGGCCGATCCAT
CTCCGCGCTGATCCGCGACGCCGTCGAGCGCACGTACGGGTCGGCGAGCGATGTCGACGAAGACATCGAGGCGATCGACC
GGGCGTTCGGAGCCTGGCAGGACCGCGATATCGACGGCGCGGCATACGTCGAAGGCCTGCGTTCGGGAGATCGCCTGGCC
GGCGCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References