Detailed information of TA system TA162240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1371288..1372623
• Replicon: chromosome
• Accession: NZ_CP055292
• Organism: Shigella sonnei strain SE6-1

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: HUX90_RS06525
• Protein ID: WP_176527851.1
• Coordinates: 1371288..1372235 (-)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A228Z6F8
• Locus tag: HUX90_RS06530
• Protein ID: WP_000152739.1
• Coordinates: 1372228..1372623 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUX90_RS06505	1367141..1367857	+	717	WP_001295734.1	N-acetylneuraminic acid outer membrane channel NanC	-
HUX90_RS06510	1367877..1368983	+	1107	WP_001298927.1	N-acetylneuraminate epimerase	-
HUX90_RS06515	1369048..1370028	+	981	WP_000991446.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HUX90_RS06520	1370036..1370686	-	651	WP_001037963.1	HNH endonuclease	-
HUX90_RS06525	1371288..1372235	-	948	WP_176527851.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HUX90_RS06530	1372228..1372623	-	396	WP_000152739.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HUX90_RS06535	1372693..1373526	-	834	WP_001192741.1	DUF4942 domain-containing protein	-
HUX90_RS06540	1373832..1375388	+	1557	WP_000202816.1	type I restriction-modification system subunit M	-
HUX90_RS06545	1375385..1376551	+	1167	WP_001293040.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	1361614..1376551	14937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-303)

Antitoxin

• Protein of unknown function DUF6088 (7-108)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 35546.71 Da
• Isoelectric Point: 4.9737

>T162240 WP_176527851.1 NZ_CP055292:c1372235-1371288 [Shigella sonnei]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMGYGERKITWDEAYSRFRSLALAILNA

Nucleotide

• Length: 948 bp

>T162240 NZ_CP071693:4489813-4490124 [Salmonella sp. SAL-045]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14605.90 Da
• Isoelectric Point: 11.6915

>AT162240 WP_000152739.1 NZ_CP055292:c1372623-1372228 [Shigella sonnei]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Nucleotide

• Length: 396 bp

>AT162240 NZ_CP071693:4490121-4490567 [Salmonella sp. SAL-045]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A228Z6F8