Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 750125..750743 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUX90_RS03665 Protein ID WP_001291435.1
Coordinates 750525..750743 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUX90_RS03660 Protein ID WP_000344800.1
Coordinates 750125..750499 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS03650 745214..746407 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUX90_RS03655 746430..749579 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HUX90_RS03660 750125..750499 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUX90_RS03665 750525..750743 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HUX90_RS03670 750915..751466 + 552 WP_000102568.1 maltose O-acetyltransferase -
HUX90_RS03675 751582..752052 + 471 WP_000136192.1 YlaC family protein -
HUX90_RS03680 752216..753766 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUX90_RS03685 753808..754161 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HUX90_RS03695 754540..754851 + 312 WP_000409911.1 MGMT family protein -
HUX90_RS03700 754882..755454 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162237 WP_001291435.1 NZ_CP055292:750525-750743 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162237 NZ_CP071693:c4072463-4072179 [Salmonella sp. SAL-045]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT162237 WP_000344800.1 NZ_CP055292:750125-750499 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT162237 NZ_CP071693:c4072695-4072453 [Salmonella sp. SAL-045]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References