162230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 108106..108728 Replicon plasmid pBspH2
Accession NZ_CP055284
Organism Acinetobacter sp. NEB 394

Toxin (Protein)


Gene name vapC Uniprot ID A0A7H8SKU4
Locus tag HUK62_RS17820 Protein ID WP_063454755.1
Coordinates 108333..108728 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag HUK62_RS17815 Protein ID WP_000401521.1
Coordinates 108106..108336 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK62_RS17800 104239..104592 + 354 WP_176538592.1 SMI1/KNR4 family protein -
HUK62_RS17805 104720..106045 + 1326 Protein_124 ISNCY family transposase -
HUK62_RS17810 106192..107525 + 1334 Protein_125 ISNCY family transposase -
HUK62_RS17815 108106..108336 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUK62_RS17820 108333..108728 + 396 WP_063454755.1 type II toxin-antitoxin system VapC family toxin Toxin
HUK62_RS17825 108889..109320 + 432 WP_176538575.1 hypothetical protein -
HUK62_RS17830 109498..110295 + 798 Protein_129 IS5 family transposase -
HUK62_RS17835 110314..110451 + 138 WP_004637095.1 hypothetical protein -
HUK62_RS17840 110563..112287 - 1725 WP_000751934.1 bifunctional protein-serine/threonine kinase/phosphatase -
HUK62_RS17845 112339..113148 - 810 WP_000323725.1 formate/nitrite transporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..161809 161809
- inside IScluster/Tn - - 101011..122997 21986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.23 Da        Isoelectric Point: 7.1633

>T162230 WP_063454755.1 NZ_CP055284:108333-108728 [Acinetobacter sp. NEB 394]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKKALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T162230 NZ_CP071693:c989031-988504 [Salmonella sp. SAL-045]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT162230 WP_000401521.1 NZ_CP055284:108106-108336 [Acinetobacter sp. NEB 394]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT162230 NZ_CP071693:c989318-989028 [Salmonella sp. SAL-045]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8SKU4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References