Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 98316..98904 | Replicon | plasmid pBspH2 |
| Accession | NZ_CP055284 | ||
| Organism | Acinetobacter sp. NEB 394 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | V2UW36 |
| Locus tag | HUK62_RS17750 | Protein ID | WP_004884492.1 |
| Coordinates | 98617..98904 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | HUK62_RS17745 | Protein ID | WP_176538571.1 |
| Coordinates | 98316..98630 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUK62_RS17715 | 93526..93840 | + | 315 | WP_038350244.1 | BrnA antitoxin family protein | - |
| HUK62_RS17720 | 93937..94464 | + | 528 | WP_000537572.1 | plasmid pRiA4b ORF-3 family protein | - |
| HUK62_RS17725 | 94570..94818 | + | 249 | WP_044425274.1 | type II toxin-antitoxin system HicA family toxin | - |
| HUK62_RS17730 | 94815..95150 | + | 336 | WP_035270373.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HUK62_RS17735 | 95289..96743 | - | 1455 | WP_004762546.1 | SulP family inorganic anion transporter | - |
| HUK62_RS17740 | 97047..97598 | + | 552 | WP_119686772.1 | hypothetical protein | - |
| HUK62_RS17745 | 98316..98630 | - | 315 | WP_176538571.1 | BrnA antitoxin family protein | Antitoxin |
| HUK62_RS17750 | 98617..98904 | - | 288 | WP_004884492.1 | BrnT family toxin | Toxin |
| HUK62_RS17755 | 99203..99601 | + | 399 | WP_026438543.1 | hypothetical protein | - |
| HUK62_RS17760 | 99684..99956 | - | 273 | WP_176538572.1 | helix-turn-helix domain-containing protein | - |
| HUK62_RS17765 | 99949..100269 | - | 321 | Protein_116 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HUK62_RS17770 | 100437..100868 | + | 432 | WP_026438531.1 | DUF600 family protein | - |
| HUK62_RS17775 | 101011..101757 | + | 747 | WP_004645384.1 | IS5-like element ISAba31 family transposase | - |
| HUK62_RS17780 | 101864..102154 | - | 291 | WP_005093398.1 | putative addiction module antidote protein | - |
| HUK62_RS17785 | 102156..102452 | - | 297 | WP_004647749.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HUK62_RS17790 | 102562..102789 | - | 228 | WP_176538573.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | katA | 1..161809 | 161809 | |
| - | inside | IScluster/Tn | - | - | 101011..122997 | 21986 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11277.63 Da Isoelectric Point: 5.2134
>T162228 WP_004884492.1 NZ_CP055284:c98904-98617 [Acinetobacter sp. NEB 394]
MEQYFEWDEAKNRKNQKKHDVSFETASLVFDDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDRYEHG
MEQYFEWDEAKNRKNQKKHDVSFETASLVFDDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDRYEHG
Download Length: 288 bp
>T162228 NZ_CP071693:825264-825677 [Salmonella sp. SAL-045]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12236.91 Da Isoelectric Point: 8.4842
>AT162228 WP_176538571.1 NZ_CP055284:c98630-98316 [Acinetobacter sp. NEB 394]
MSMVRYSRKELNEKFSDKQDAEIQRLLAKGTVPDDQLDLSDMPEITDWSNAVRHNQLYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSRKELNEKFSDKQDAEIQRLLAKGTVPDDQLDLSDMPEITDWSNAVRHNQLYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT162228 NZ_CP071693:825017-825283 [Salmonella sp. SAL-045]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|