162226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 38138..38715 Replicon plasmid pBspH2
Accession NZ_CP055284
Organism Acinetobacter sp. NEB 394

Toxin (Protein)


Gene name hicA Uniprot ID N8ZPI0
Locus tag HUK62_RS17430 Protein ID WP_004812233.1
Coordinates 38138..38386 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A062BK26
Locus tag HUK62_RS17435 Protein ID WP_005404859.1
Coordinates 38383..38715 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK62_RS17400 34446..34907 + 462 Protein_43 hypothetical protein -
HUK62_RS17405 34913..35464 + 552 WP_016658769.1 macro domain-containing protein -
HUK62_RS17410 35466..35852 - 387 WP_004769969.1 type II toxin-antitoxin system death-on-curing family toxin -
HUK62_RS17415 35849..36028 - 180 WP_016658770.1 hypothetical protein -
HUK62_RS17420 36078..36413 - 336 WP_035363642.1 hypothetical protein -
HUK62_RS17425 36911..37477 + 567 WP_000678311.1 recombinase family protein -
HUK62_RS17430 38138..38386 + 249 WP_004812233.1 type II toxin-antitoxin system HicA family toxin Toxin
HUK62_RS17435 38383..38715 + 333 WP_005404859.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUK62_RS17440 38901..39272 + 372 WP_032029059.1 rod shape-determining protein -
HUK62_RS17445 39324..39809 - 486 Protein_52 IS3 family transposase -
HUK62_RS17450 39889..41130 - 1242 WP_004826931.1 group II intron reverse transcriptase/maturase -
HUK62_RS17455 41644..42377 - 734 Protein_54 IS3 family transposase -
HUK62_RS17460 42557..43689 - 1133 Protein_55 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..161809 161809
- inside IScluster/Tn - - 16001..44383 28382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9436.02 Da        Isoelectric Point: 10.1337

>T162226 WP_004812233.1 NZ_CP055284:38138-38386 [Acinetobacter sp. NEB 394]
MGKTEKLLEKFGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFFNEKTEHMILLHRPHPENEIKGGALKAVKQALKQEG
FL

Download         Length: 249 bp

>T162226 NZ_CP071693:310515-310883 [Salmonella sp. SAL-045]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12239.00 Da        Isoelectric Point: 4.9061

>AT162226 WP_005404859.1 NZ_CP055284:38383-38715 [Acinetobacter sp. NEB 394]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKALEKAFQESVDGYLESCAELGKSPDQPFKGTFNVRISPE
LHRKAVLASSNSLNAFVSEAIQEKLMRLGA

Download         Length: 333 bp

>AT162226 NZ_CP071693:310297-310518 [Salmonella sp. SAL-045]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8ZPI0

Antitoxin

Source ID Structure
AlphaFold DB A0A062BK26

References