Detailed information of TA system TA162211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2772558..2773162
• Replicon: chromosome
• Accession: NZ_CP055276
• Organism: Enterobacter mori strain CX01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2T4Y605
• Locus tag: HUI94_RS13050
• Protein ID: WP_041911637.1
• Coordinates: 2772558..2772743 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HUI94_RS13055
• Protein ID: WP_108418126.1
• Coordinates: 2772758..2773162 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI94_RS13030 (HUI94_13005)	2767940..2768824	-	885	WP_042718576.1	ROK family protein	-
HUI94_RS13035 (HUI94_13010)	2768990..2770528	+	1539	WP_042716601.1	aldehyde dehydrogenase family protein	-
HUI94_RS13040 (HUI94_13015)	2770525..2771490	-	966	WP_218400060.1	LysR family transcriptional regulator	-
HUI94_RS13045 (HUI94_13020)	2771608..2772348	+	741	WP_218400062.1	MipA/OmpV family protein	-
HUI94_RS13050 (HUI94_13025)	2772558..2772743	+	186	WP_041911637.1	type II toxin-antitoxin system HicA family toxin	Toxin
HUI94_RS13055 (HUI94_13030)	2772758..2773162	+	405	WP_108418126.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HUI94_RS13060 (HUI94_13035)	2773218..2775167	-	1950	WP_218400064.1	glycoside hydrolase family 127 protein	-
HUI94_RS13065 (HUI94_13040)	2775178..2776578	-	1401	WP_218400066.1	MFS transporter	-
HUI94_RS13070 (HUI94_13045)	2776804..2777622	+	819	WP_109492507.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.04 Da
• Isoelectric Point: 11.2341

>T162211 WP_041911637.1 NZ_CP055276:2772558-2772743 [Enterobacter mori]
VKSADVITVLIGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T162211 NZ_CP071690:836177-836575 [Salmonella sp. SAL-020]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14970.71 Da
• Isoelectric Point: 4.3197

>AT162211 WP_108418126.1 NZ_CP055276:2772758-2773162 [Enterobacter mori]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDDALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSYVSEHPQFGNRSAFLAEAARRVLP

Nucleotide

• Length: 405 bp

>AT162211 NZ_CP071690:835950-836177 [Salmonella sp. SAL-020]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A2T4Y605