Detailed information of TA system TA162210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-RHH
• Location: 2647067..2647683
• Replicon: chromosome
• Accession: NZ_CP055276
• Organism: Enterobacter mori strain CX01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUI94_RS12480
• Protein ID: WP_109492490.1
• Coordinates: 2647312..2647683 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUI94_RS12475
• Protein ID: WP_109492491.1
• Coordinates: 2647067..2647309 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI94_RS12450 (HUI94_12430)	2642097..2643920	+	1824	WP_100167579.1	ribosome-dependent GTPase TypA	-
HUI94_RS12455 (HUI94_12435)	2644053..2644652	+	600	WP_100167578.1	glucose-1-phosphatase	-
HUI94_RS12460 (HUI94_12440)	2644646..2645527	+	882	WP_100167577.1	virulence factor BrkB family protein	-
HUI94_RS12465 (HUI94_12445)	2645524..2645961	+	438	WP_014833798.1	D-aminoacyl-tRNA deacylase	-
HUI94_RS12470 (HUI94_12450)	2646006..2646947	+	942	WP_042716391.1	fatty acid biosynthesis protein FabY	-
HUI94_RS12475 (HUI94_12455)	2647067..2647309	+	243	WP_109492491.1	ribbon-helix-helix protein, CopG family	Antitoxin
HUI94_RS12480 (HUI94_12460)	2647312..2647683	+	372	WP_109492490.1	type II toxin-antitoxin system VapC family toxin	Toxin
HUI94_RS12485 (HUI94_12465)	2647723..2648652	-	930	WP_010436850.1	formate dehydrogenase accessory protein FdhE	-
HUI94_RS12490 (HUI94_12470)	2648649..2649284	-	636	WP_010436852.1	formate dehydrogenase cytochrome b556 subunit	-
HUI94_RS12495 (HUI94_12475)	2649281..2650183	-	903	WP_214598973.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-109)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13594.73 Da
• Isoelectric Point: 6.8715

>T162210 WP_109492490.1 NZ_CP055276:2647312-2647683 [Enterobacter mori]
MEQMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIVDITREIAERSVLLR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Nucleotide

• Length: 372 bp

>T162210 NZ_CP071690:825273-825686 [Salmonella sp. SAL-020]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9469.67 Da
• Isoelectric Point: 4.2803

>AT162210 WP_109492491.1 NZ_CP055276:2647067-2647309 [Enterobacter mori]
MTLLADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT162210 NZ_CP071690:825026-825292 [Salmonella sp. SAL-020]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA