Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 2647067..2647683 Replicon chromosome
Accession NZ_CP055276
Organism Enterobacter mori strain CX01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUI94_RS12480 Protein ID WP_109492490.1
Coordinates 2647312..2647683 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUI94_RS12475 Protein ID WP_109492491.1
Coordinates 2647067..2647309 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUI94_RS12450 (HUI94_12430) 2642097..2643920 + 1824 WP_100167579.1 ribosome-dependent GTPase TypA -
HUI94_RS12455 (HUI94_12435) 2644053..2644652 + 600 WP_100167578.1 glucose-1-phosphatase -
HUI94_RS12460 (HUI94_12440) 2644646..2645527 + 882 WP_100167577.1 virulence factor BrkB family protein -
HUI94_RS12465 (HUI94_12445) 2645524..2645961 + 438 WP_014833798.1 D-aminoacyl-tRNA deacylase -
HUI94_RS12470 (HUI94_12450) 2646006..2646947 + 942 WP_042716391.1 fatty acid biosynthesis protein FabY -
HUI94_RS12475 (HUI94_12455) 2647067..2647309 + 243 WP_109492491.1 ribbon-helix-helix protein, CopG family Antitoxin
HUI94_RS12480 (HUI94_12460) 2647312..2647683 + 372 WP_109492490.1 type II toxin-antitoxin system VapC family toxin Toxin
HUI94_RS12485 (HUI94_12465) 2647723..2648652 - 930 WP_010436850.1 formate dehydrogenase accessory protein FdhE -
HUI94_RS12490 (HUI94_12470) 2648649..2649284 - 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
HUI94_RS12495 (HUI94_12475) 2649281..2650183 - 903 WP_214598973.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13594.73 Da        Isoelectric Point: 6.8715

>T162210 WP_109492490.1 NZ_CP055276:2647312-2647683 [Enterobacter mori]
MEQMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIVDITREIAERSVLLR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Download         Length: 372 bp

>T162210 NZ_CP071690:825273-825686 [Salmonella sp. SAL-020]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.67 Da        Isoelectric Point: 4.2803

>AT162210 WP_109492491.1 NZ_CP055276:2647067-2647309 [Enterobacter mori]
MTLLADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT162210 NZ_CP071690:825026-825292 [Salmonella sp. SAL-020]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References