Detailed information of TA system TA162209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2515279..2515941
• Replicon: chromosome
• Accession: NZ_CP055276
• Organism: Enterobacter mori strain CX01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUI94_RS11855
• Protein ID: WP_215230450.1
• Coordinates: 2515279..2515677 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUI94_RS11860
• Protein ID: WP_109081969.1
• Coordinates: 2515681..2515941 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI94_RS11825 (HUI94_11805)	2511112..2511342	-	231	WP_218399960.1	hypothetical protein	-
HUI94_RS11830 (HUI94_11810)	2511433..2511888	-	456	WP_218399962.1	hypothetical protein	-
HUI94_RS11835 (HUI94_11815)	2512078..2512326	-	249	WP_010426483.1	hypothetical protein	-
HUI94_RS11840 (HUI94_11820)	2512436..2513389	-	954	WP_218399964.1	helix-turn-helix domain-containing protein	-
HUI94_RS11845 (HUI94_11825)	2513415..2514194	-	780	WP_042714405.1	MBL fold metallo-hydrolase	-
HUI94_RS11850 (HUI94_11830)	2514290..2515090	-	801	WP_182946140.1	lipoprotein NlpA	-
HUI94_RS11855 (HUI94_11835)	2515279..2515677	-	399	WP_215230450.1	type II toxin-antitoxin system VapC family toxin	Toxin
HUI94_RS11860 (HUI94_11840)	2515681..2515941	-	261	WP_109081969.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HUI94_RS11865 (HUI94_11845)	2516059..2517558	-	1500	WP_042714402.1	MDR family MFS transporter	-
HUI94_RS11870 (HUI94_11850)	2517637..2518284	+	648	WP_089598300.1	TetR/AcrR family transcriptional regulator	-
HUI94_RS11875 (HUI94_11855)	2518281..2518700	-	420	WP_218399966.1	GNAT family N-acetyltransferase	-
HUI94_RS11880 (HUI94_11860)	2518887..2519456	+	570	WP_218399968.1	TetR/AcrR family transcriptional regulator	-
HUI94_RS11885 (HUI94_11865)	2519605..2520726	+	1122	WP_100167482.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2502616..2515941	13325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14784.03 Da
• Isoelectric Point: 6.3267

>T162209 WP_215230450.1 NZ_CP055276:c2515677-2515279 [Enterobacter mori]
MLHMLDTNIVSHLVRQHPEVLNQYSRIAPEKMCISSVTEAELLYGVAKKQNNQLHKTILEFLKTITICDWDSEAAAAYGE
LRAVMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLRVEDWTTAA

Nucleotide

• Length: 399 bp

>T162209 NZ_CP071690:358943-359218 [Salmonella sp. SAL-020]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10104.44 Da
• Isoelectric Point: 9.6539

>AT162209 WP_109081969.1 NZ_CP055276:c2515941-2515681 [Enterobacter mori]
MERTVKLIKKGRKQAVVLPAEFAFDTESVYIRRDDEGNIVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYSTR
DPLEGL

Nucleotide

• Length: 261 bp

>AT162209 NZ_CP071690:358680-358940 [Salmonella sp. SAL-020]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA