Detailed information of TA system TA162208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2079123..2079639
• Replicon: chromosome
• Accession: NZ_CP055276
• Organism: Enterobacter mori strain CX01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUI94_RS09750
• Protein ID: WP_109082346.1
• Coordinates: 2079123..2079407 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: HUI94_RS09755
• Protein ID: WP_008501400.1
• Coordinates: 2079397..2079639 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI94_RS09735 (HUI94_09720)	2074399..2076042	+	1644	WP_215230541.1	alpha,alpha-phosphotrehalase	-
HUI94_RS09740 (HUI94_09725)	2076418..2078556	+	2139	WP_218402370.1	anaerobic ribonucleoside-triphosphate reductase	-
HUI94_RS09745 (HUI94_09730)	2078655..2079119	+	465	WP_100165609.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HUI94_RS09750 (HUI94_09735)	2079123..2079407	-	285	WP_109082346.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUI94_RS09755 (HUI94_09740)	2079397..2079639	-	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HUI94_RS09760 (HUI94_09745)	2079717..2081627	-	1911	WP_218402372.1	PRD domain-containing protein	-
HUI94_RS09765 (HUI94_09750)	2081647..2082783	-	1137	WP_218402374.1	lactonase family protein	-
HUI94_RS09770 (HUI94_09755)	2082899..2083639	-	741	WP_218402376.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10894.69 Da
• Isoelectric Point: 10.1988

>T162208 WP_109082346.1 NZ_CP055276:c2079407-2079123 [Enterobacter mori]
MTYELAFDPRALKEWSKLGETVKDQFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T162208 NZ_CP071690:310524-310892 [Salmonella sp. SAL-020]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT162208 WP_008501400.1 NZ_CP055276:c2079639-2079397 [Enterobacter mori]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT162208 NZ_CP071690:310306-310527 [Salmonella sp. SAL-020]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3