Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1474598..1475218 Replicon chromosome
Accession NZ_CP055276
Organism Enterobacter mori strain CX01

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag HUI94_RS07060 Protein ID WP_010428174.1
Coordinates 1475000..1475218 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HUI94_RS07055 Protein ID WP_008499288.1
Coordinates 1474598..1474972 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUI94_RS07045 (HUI94_07025) 1469726..1470919 + 1194 WP_042716154.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUI94_RS07050 (HUI94_07030) 1470942..1474088 + 3147 WP_042716155.1 multidrug efflux RND transporter permease subunit AcrB -
HUI94_RS07055 (HUI94_07035) 1474598..1474972 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HUI94_RS07060 (HUI94_07040) 1475000..1475218 + 219 WP_010428174.1 HHA domain-containing protein Toxin
HUI94_RS07065 (HUI94_07045) 1475428..1475979 + 552 WP_218402099.1 maltose O-acetyltransferase -
HUI94_RS07070 (HUI94_07050) 1476097..1476564 + 468 WP_089597999.1 YlaC family protein -
HUI94_RS07075 (HUI94_07055) 1476536..1477996 - 1461 WP_218402101.1 PLP-dependent aminotransferase family protein -
HUI94_RS07080 (HUI94_07060) 1478098..1478808 + 711 WP_089597997.1 GNAT family protein -
HUI94_RS07085 (HUI94_07065) 1478805..1478945 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HUI94_RS07090 (HUI94_07070) 1478948..1479208 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T162207 WP_010428174.1 NZ_CP055276:1475000-1475218 [Enterobacter mori]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T162207 NZ_CP071690:200452-200937 [Salmonella sp. SAL-020]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT162207 WP_008499288.1 NZ_CP055276:1474598-1474972 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT162207 NZ_CP071690:200177-200464 [Salmonella sp. SAL-020]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References