Detailed information of TA system TA162206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 983919..984832
• Replicon: chromosome
• Accession: NZ_CP055276
• Organism: Enterobacter mori strain CX01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HUI94_RS04730
• Protein ID: WP_218401773.1
• Coordinates: 984359..984832 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A2J0PMR8
• Locus tag: HUI94_RS04725
• Protein ID: WP_023337017.1
• Coordinates: 983919..984362 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI94_RS04710 (HUI94_04685)	979855..981576	+	1722	WP_100165176.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
HUI94_RS04715 (HUI94_04690)	981623..982327	+	705	WP_100165177.1	leucyl/phenylalanyl-tRNA--protein transferase	-
HUI94_RS04720 (HUI94_04695)	982612..982830	+	219	WP_002211347.1	translation initiation factor IF-1	-
HUI94_RS04725 (HUI94_04700)	983919..984362	+	444	WP_023337017.1	DUF2384 domain-containing protein	Antitoxin
HUI94_RS04730 (HUI94_04705)	984359..984832	+	474	WP_218401773.1	RES family NAD+ phosphorylase	Toxin
HUI94_RS04735 (HUI94_04710)	984854..985408	-	555	WP_218401781.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
HUI94_RS04740 (HUI94_04715)	985418..986416	-	999	WP_218401783.1	type I-F CRISPR-associated protein Csy3	-
HUI94_RS04745 (HUI94_04720)	986430..987365	-	936	WP_218401785.1	type I-F CRISPR-associated protein Csy2	-
HUI94_RS04750 (HUI94_04725)	987362..988672	-	1311	WP_218401787.1	type I-F CRISPR-associated protein Csy1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17539.84 Da
• Isoelectric Point: 4.8041

>T162206 WP_218401773.1 NZ_CP055276:984359-984832 [Enterobacter mori]
MIFYRLVTGSFANEAWSGSGANQYGGRWNHKGHPTVYVSTSISLASLEILVHVRKDTVLNQYQLFSIEIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFHTALNSVQQLPFIFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T162206 NZ_CP071688:c28031-27750 [Salmonella sp. SAL-007]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16349.68 Da
• Isoelectric Point: 7.2062

>AT162206 WP_023337017.1 NZ_CP055276:983919-984362 [Enterobacter mori]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT162206 NZ_CP071688:c28272-28021 [Salmonella sp. SAL-007]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2J0PMR8