Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2664579..2665107 Replicon chromosome
Accession NZ_CP055265
Organism Agrobacterium vitis strain CG412

Toxin (Protein)


Gene name stbE Uniprot ID A0A368NT05
Locus tag AVCG412_RS12550 Protein ID WP_060718298.1
Coordinates 2664817..2665107 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B9JS94
Locus tag AVCG412_RS12545 Protein ID WP_015917134.1
Coordinates 2664579..2664827 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVCG412_RS12530 (AVCG412_12500) 2662354..2662920 + 567 WP_060718296.1 sarcosine oxidase subunit gamma -
AVCG412_RS12535 (AVCG412_12505) 2662927..2663988 - 1062 WP_060718496.1 SDR family oxidoreductase -
AVCG412_RS12540 (AVCG412_12510) 2664087..2664479 + 393 WP_060718297.1 helix-turn-helix domain-containing protein -
AVCG412_RS12545 (AVCG412_12515) 2664579..2664827 + 249 WP_015917134.1 antitoxin Antitoxin
AVCG412_RS12550 (AVCG412_12520) 2664817..2665107 + 291 WP_060718298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AVCG412_RS12555 (AVCG412_12525) 2665248..2666354 - 1107 WP_060718299.1 TRAP transporter substrate-binding protein -
AVCG412_RS12560 (AVCG412_12530) 2666556..2667320 + 765 WP_060718497.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
AVCG412_RS12565 (AVCG412_12535) 2667323..2668282 - 960 WP_060718300.1 2-hydroxyacid dehydrogenase -
AVCG412_RS12570 (AVCG412_12540) 2668298..2669320 - 1023 WP_060718301.1 LacI family DNA-binding transcriptional regulator -
AVCG412_RS12575 (AVCG412_12545) 2669428..2669970 - 543 WP_060718302.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11010.82 Da        Isoelectric Point: 10.6241

>T162205 WP_060718298.1 NZ_CP055265:2664817-2665107 [Agrobacterium vitis]
MSYELAFVDAALKEWRKLDHSVREQFKKKLAERCTNPRLPSAQLSGAKDRYKIKLRGAGYRLVYEVRDKDIIIVVVAVGR
RDRSGVYKAAADRSVL

Download         Length: 291 bp

>T162205 NZ_CP071687:c61626-61321 [Salmonella sp. SAL-007]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8743.98 Da        Isoelectric Point: 4.2404

>AT162205 WP_015917134.1 NZ_CP055265:2664579-2664827 [Agrobacterium vitis]
MTHIVLAEVTASVSELKKNPMGTVAAGDGAAVAILNRNEPAFYCVPASAYEAMIERLDDLELNAIADARANDRVVKVTLD
EL

Download         Length: 249 bp

>AT162205 NZ_CP071687:c61846-61628 [Salmonella sp. SAL-007]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A368NT05

Antitoxin

Source ID Structure
AlphaFold DB B9JS94

References