Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2215280..2215916 Replicon chromosome
Accession NZ_CP055263
Organism Metabacillus sp. KUDC1714

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag HUW50_RS10565 Protein ID WP_026562078.1
Coordinates 2215566..2215916 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0M2PIB9
Locus tag HUW50_RS10560 Protein ID WP_026562079.1
Coordinates 2215280..2215561 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW50_RS10545 2211368..2211730 + 363 WP_066332161.1 holo-ACP synthase -
HUW50_RS10550 2212167..2213189 + 1023 WP_157094388.1 outer membrane lipoprotein-sorting protein -
HUW50_RS10555 2213641..2214810 + 1170 WP_066332150.1 alanine racemase -
HUW50_RS10560 2215280..2215561 + 282 WP_026562079.1 hypothetical protein Antitoxin
HUW50_RS10565 2215566..2215916 + 351 WP_026562078.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
HUW50_RS10570 2216114..2216944 + 831 WP_066332142.1 STAS domain-containing protein -
HUW50_RS10575 2216948..2217310 + 363 WP_066332137.1 STAS domain-containing protein -
HUW50_RS10580 2217314..2217715 + 402 WP_066332128.1 anti-sigma regulatory factor -
HUW50_RS10585 2217726..2218733 + 1008 WP_066332120.1 PP2C family protein-serine/threonine phosphatase -
HUW50_RS10590 2218789..2219121 + 333 WP_066332111.1 anti-sigma factor antagonist -
HUW50_RS10595 2219118..2219600 + 483 WP_066332103.1 anti-sigma B factor RsbW -
HUW50_RS10600 2219566..2220357 + 792 WP_066332098.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T162201 WP_026562078.1 NZ_CP055263:2215566-2215916 [Metabacillus sp. KUDC1714]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T162201 NZ_CP071686:c4072646-4072362 [Salmonella sp. SAL-007]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10556.00 Da        Isoelectric Point: 5.8851

>AT162201 WP_026562079.1 NZ_CP055263:2215280-2215561 [Metabacillus sp. KUDC1714]
VSESSATTEILIQLPQALVSELDGLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT162201 NZ_CP071686:c4072878-4072636 [Salmonella sp. SAL-007]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2PN83

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2PIB9

References