Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 126405..127048 Replicon plasmid pAH62-3
Accession NZ_CP055262
Organism Escherichia coli strain AH62

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag HU676_RS24505 Protein ID WP_001044768.1
Coordinates 126405..126821 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag HU676_RS24510 Protein ID WP_001261287.1
Coordinates 126818..127048 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU676_RS24490 122904..123494 - 591 WP_000194575.1 hypothetical protein -
HU676_RS24495 123494..123751 - 258 WP_000343085.1 hypothetical protein -
HU676_RS24500 124105..126243 + 2139 WP_000350638.1 AAA family ATPase -
HU676_RS24505 126405..126821 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
HU676_RS24510 126818..127048 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HU676_RS24515 127344..127634 + 291 WP_000111771.1 hypothetical protein -
HU676_RS24520 127624..128523 + 900 WP_000963206.1 nucleotide-binding protein -
HU676_RS24525 128573..130798 - 2226 WP_000698737.1 phage T7 exclusion protein -
HU676_RS24530 130800..131888 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sitABCD / blaTEM-1A / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / aac(3)-IId / aadA5 / qacE / sul1 / mph(A) iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..136694 136694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T162200 WP_001044768.1 NZ_CP055262:c126821-126405 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T162200 NZ_CP071686:c4031545-4031237 [Salmonella sp. SAL-007]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT162200 WP_001261287.1 NZ_CP055262:c127048-126818 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT162200 NZ_CP071686:c4031787-4031548 [Salmonella sp. SAL-007]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References