Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3514786..3515404 Replicon chromosome
Accession NZ_CP055259
Organism Escherichia coli strain AH62

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HU676_RS16930 Protein ID WP_001291435.1
Coordinates 3515186..3515404 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HU676_RS16925 Protein ID WP_000344800.1
Coordinates 3514786..3515160 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU676_RS16915 3509875..3511068 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HU676_RS16920 3511091..3514240 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HU676_RS16925 3514786..3515160 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HU676_RS16930 3515186..3515404 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HU676_RS16935 3515576..3516127 + 552 WP_000102564.1 maltose O-acetyltransferase -
HU676_RS16940 3516243..3516713 + 471 WP_000136192.1 YlaC family protein -
HU676_RS16945 3516877..3518427 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HU676_RS16950 3518469..3518822 - 354 WP_042017122.1 DUF1428 family protein -
HU676_RS16960 3519201..3519512 + 312 WP_000409911.1 MGMT family protein -
HU676_RS16965 3519543..3520115 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162179 WP_001291435.1 NZ_CP055259:3515186-3515404 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162179 NZ_CP071636:c219519-219088 [Rhizobium sp. NZLR1]
ATGATATTGCTGGACACCAACGTCATATCAGAGCCGTGGAGATCGGTTCCCGACGTGGCAGTGATCGCTTGGTTGGACGC
ACAAGCAATCGAGACACTGTTCCTTTCTACCATAACAATTGCCGAACTTCGTTTTGGGATTGCTTCCATGCCCCCAGGCA
AACGGCAGGCTATCCTTCACGATCGCCTGGAGCGCGAAGTGCTTCTGCATTTTGTCGAGCGCATTCTACCCTTCGGCGTC
ACCACCTCGCAGTTTTATTCAGACCTCATGGCGCGTGCTCGGCTGTCCGGGAAAGCGATCGGCAAAGCTGATGGATATAT
TGCGGCCACGGCAGCGGCGCACGGTCTCGCGGTCGCGACGCGCGACACGAGCCCTTTCGAGGCCGCCGGGCTGAAGGTGA
TCAATCCTTGGTCTTCACCAAAATCATCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT162179 WP_000344800.1 NZ_CP055259:3514786-3515160 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT162179 NZ_CP071636:c219770-219516 [Rhizobium sp. NZLR1]
ATGCCAGCGGTCACCATTCGCAATCTCTCGGATGAGACACATCGCGCCCTGCGGGTGCGAGCAGCTCATCATGGCAGAAG
CACCGAGGCTGAAATCCGTGACATCCTCGAGGCTGCCGTTCGTCCATCTGAGCGCGTGAAACTCGGCTCTTTACTTGCGG
CGATAGGTCGGGATGCCGAGCTTTCCGACGATGATGTTGGAGCCCTGCAGCAGGGTCGCGATAAGGCACCTGCGGAGCCG
ATGACGTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References