Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2842970..2844690 Replicon chromosome
Accession NZ_CP055259
Organism Escherichia coli strain AH62

Toxin (Protein)


Gene name pmenT Uniprot ID A0A7U9J2A7
Locus tag HU676_RS13790 Protein ID WP_000312833.1
Coordinates 2842970..2843626 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID B7UP19
Locus tag HU676_RS13795 Protein ID WP_000634203.1
Coordinates 2843623..2844690 (+) Length 356 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU676_RS13770 2838370..2838624 - 255 WP_154670580.1 hypothetical protein -
HU676_RS13775 2838906..2839145 + 240 WP_001431807.1 hypothetical protein -
HU676_RS13780 2839185..2841623 + 2439 WP_000985465.1 type I restriction-modification system subunit M -
HU676_RS13785 2841623..2842957 + 1335 WP_000228013.1 restriction endonuclease subunit S -
HU676_RS13790 2842970..2843626 + 657 WP_000312833.1 DUF4433 domain-containing protein Toxin
HU676_RS13795 2843623..2844690 + 1068 WP_000634203.1 macro domain-containing protein Antitoxin
HU676_RS13800 2844709..2847804 + 3096 WP_000108735.1 HsdR family type I site-specific deoxyribonuclease -
HU676_RS13805 2847804..2848520 + 717 WP_001122107.1 M48 family metallopeptidase -
HU676_RS13810 2848876..2849469 + 594 Protein_2704 IS3-like element IS600 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 2814509..2859650 45141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(17-217)

Antitoxin

(18-129)


Sequences


Toxin        


Download         Length: 219 a.a.        Molecular weight: 25233.56 Da        Isoelectric Point: 6.2145

>T162178 WP_000312833.1 NZ_CP055259:2842970-2843626 [Escherichia coli]
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS

Download         Length: 657 bp

>T162178 NZ_CP071635:c265591-264722 [Rhizobium sp. NZLR1]
ATGGCTAAAGAAATCAGAAACGTCGGCGCCTCGGTGCGCGCCCGCCTATTGCAACTCGCCAAGGCAAGCGGGCAAAGCTT
CGATCTGGTCCTGACGCGTTTTGCTCTTGAACGGTTATTGTTCCGGCTTAGCCAGTCGCCCCACGCCGGTCGCTTCGTTC
TAAAAGGGGCGATGTTGATGATGAGTTGGTTCGACAATCCGCACCGAGGCACGCGCGACCTCGACCTTTTGGGTTTCGGT
GATCCGAGTCCGGACCCGATGCTTGAGACATTTCGGGAAATTCTGGCGCAAGAGGCCGACGATGGCGTTACGTTCGACGC
TGATACGCTGCATGTGGATCGTATTCGCGAGGCATTGGATTATGGTGGGCTCAGGCTGCGGGTGATCGCTTCGATCAGCG
GAGCCCGGATTAACCTGACGATCGACATCGGTTTTGGCGATGCGCTTGAGCCTGGGGTGGAGGTTTTGGATTATCCTTCC
ATGCTCGATTTTCCGATGCCGCGGCTTCGGGCCTATGCGCGAGAAACGGTCATTGCCGAGAAGTTCCAGGCAATGGTGAT
GCTGGGGCGAGTAAACAGCCGTATGAAGGATTTCTACGACATCTGGATCCTCAGCAGGTCTTTCGACTTCGGCGATGATC
GGCTGGCGCGCGCAATAGCCGCTACCTTTGATCGCCGCGAGACATCGATCCCCATTGACCTCCCCGACGCCCTAACGGAC
GCCTTTGCCAAGGACCAGCAAAAGCAGCGGCAATGGCGAGCTTTCGTTGAAGGCGTTGCACACAATCCTGGCGATCTGAC
AGACGTCATCGCGGAGATTGCCACATTCCTGATGCCGCACGCGGTTGCGGCTGCGAGGCTGGACGAATGA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40672.70 Da        Isoelectric Point: 5.6927

>AT162178 WP_000634203.1 NZ_CP055259:2843623-2844690 [Escherichia coli]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT162178 NZ_CP071635:c266201-265584 [Rhizobium sp. NZLR1]
ATGCCCGGTTCCGTCACGCAACGCCAGATCGCCCGAACCGTGCTAACTGAGCGCGGAATAGCACGTTTGGTGGAACTGCG
GAACGCAGGTGTGACGGCTGCCACCATGAGCCGAATGGAACGAGATGGTGAAGTGCTCCGGCTTGCCCGCGGTCTTTATC
AACTTCCTGATGCGCAGCTCGACGTCAACCACAGCCTGGCGGAGGTTGCCAAACGCGCACCCAAAGGCGTTATCTGCCTC
GTTTCGGCACTGGCGTTCCACGGCCTGACAGATCAGCTCCCAGGACAAATCTGGCTTGCCATAGGCCGTAAGGACTGGGC
TCCGAAACTGGACGGCCCCGCTATGCGCATCGTGCGTTTCACAGACGGCCTTCTCAACGAAAGCGTCGAACCCCATGTCA
TTGAAGGCGTTCCCGTGAGGGTCTTTGGAATTGCCAAGACAATTGCCGATTGCTTTCGCTATCGCAACAAGATCGGCCTT
TCGGTAGCGATAGAAGGGCTGCAGGAGGCGCTGCGGCAACGAAGGGCTACTCCTGGCGAAATCGCCAACCAGGCCGAACG
CGGTGGCGTCGGATCGGTGATCCGGCCGTATCTCGAGGCGCTGACCGCCAATGGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9J2A7


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9J2B9

References