Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
Location | 2842970..2844690 | Replicon | chromosome |
Accession | NZ_CP055259 | ||
Organism | Escherichia coli strain AH62 |
Toxin (Protein)
Gene name | pmenT | Uniprot ID | A0A7U9J2A7 |
Locus tag | HU676_RS13790 | Protein ID | WP_000312833.1 |
Coordinates | 2842970..2843626 (+) | Length | 219 a.a. |
Antitoxin (Protein)
Gene name | pmenA | Uniprot ID | B7UP19 |
Locus tag | HU676_RS13795 | Protein ID | WP_000634203.1 |
Coordinates | 2843623..2844690 (+) | Length | 356 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HU676_RS13770 | 2838370..2838624 | - | 255 | WP_154670580.1 | hypothetical protein | - |
HU676_RS13775 | 2838906..2839145 | + | 240 | WP_001431807.1 | hypothetical protein | - |
HU676_RS13780 | 2839185..2841623 | + | 2439 | WP_000985465.1 | type I restriction-modification system subunit M | - |
HU676_RS13785 | 2841623..2842957 | + | 1335 | WP_000228013.1 | restriction endonuclease subunit S | - |
HU676_RS13790 | 2842970..2843626 | + | 657 | WP_000312833.1 | DUF4433 domain-containing protein | Toxin |
HU676_RS13795 | 2843623..2844690 | + | 1068 | WP_000634203.1 | macro domain-containing protein | Antitoxin |
HU676_RS13800 | 2844709..2847804 | + | 3096 | WP_000108735.1 | HsdR family type I site-specific deoxyribonuclease | - |
HU676_RS13805 | 2847804..2848520 | + | 717 | WP_001122107.1 | M48 family metallopeptidase | - |
HU676_RS13810 | 2848876..2849469 | + | 594 | Protein_2704 | IS3-like element IS600 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | csgB / csgD / csgE / csgF / csgG | 2814509..2859650 | 45141 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 219 a.a. Molecular weight: 25233.56 Da Isoelectric Point: 6.2145
>T162178 WP_000312833.1 NZ_CP055259:2842970-2843626 [Escherichia coli]
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS
Download Length: 657 bp
>T162178 NZ_CP071635:c265591-264722 [Rhizobium sp. NZLR1]
ATGGCTAAAGAAATCAGAAACGTCGGCGCCTCGGTGCGCGCCCGCCTATTGCAACTCGCCAAGGCAAGCGGGCAAAGCTT
CGATCTGGTCCTGACGCGTTTTGCTCTTGAACGGTTATTGTTCCGGCTTAGCCAGTCGCCCCACGCCGGTCGCTTCGTTC
TAAAAGGGGCGATGTTGATGATGAGTTGGTTCGACAATCCGCACCGAGGCACGCGCGACCTCGACCTTTTGGGTTTCGGT
GATCCGAGTCCGGACCCGATGCTTGAGACATTTCGGGAAATTCTGGCGCAAGAGGCCGACGATGGCGTTACGTTCGACGC
TGATACGCTGCATGTGGATCGTATTCGCGAGGCATTGGATTATGGTGGGCTCAGGCTGCGGGTGATCGCTTCGATCAGCG
GAGCCCGGATTAACCTGACGATCGACATCGGTTTTGGCGATGCGCTTGAGCCTGGGGTGGAGGTTTTGGATTATCCTTCC
ATGCTCGATTTTCCGATGCCGCGGCTTCGGGCCTATGCGCGAGAAACGGTCATTGCCGAGAAGTTCCAGGCAATGGTGAT
GCTGGGGCGAGTAAACAGCCGTATGAAGGATTTCTACGACATCTGGATCCTCAGCAGGTCTTTCGACTTCGGCGATGATC
GGCTGGCGCGCGCAATAGCCGCTACCTTTGATCGCCGCGAGACATCGATCCCCATTGACCTCCCCGACGCCCTAACGGAC
GCCTTTGCCAAGGACCAGCAAAAGCAGCGGCAATGGCGAGCTTTCGTTGAAGGCGTTGCACACAATCCTGGCGATCTGAC
AGACGTCATCGCGGAGATTGCCACATTCCTGATGCCGCACGCGGTTGCGGCTGCGAGGCTGGACGAATGA
ATGGCTAAAGAAATCAGAAACGTCGGCGCCTCGGTGCGCGCCCGCCTATTGCAACTCGCCAAGGCAAGCGGGCAAAGCTT
CGATCTGGTCCTGACGCGTTTTGCTCTTGAACGGTTATTGTTCCGGCTTAGCCAGTCGCCCCACGCCGGTCGCTTCGTTC
TAAAAGGGGCGATGTTGATGATGAGTTGGTTCGACAATCCGCACCGAGGCACGCGCGACCTCGACCTTTTGGGTTTCGGT
GATCCGAGTCCGGACCCGATGCTTGAGACATTTCGGGAAATTCTGGCGCAAGAGGCCGACGATGGCGTTACGTTCGACGC
TGATACGCTGCATGTGGATCGTATTCGCGAGGCATTGGATTATGGTGGGCTCAGGCTGCGGGTGATCGCTTCGATCAGCG
GAGCCCGGATTAACCTGACGATCGACATCGGTTTTGGCGATGCGCTTGAGCCTGGGGTGGAGGTTTTGGATTATCCTTCC
ATGCTCGATTTTCCGATGCCGCGGCTTCGGGCCTATGCGCGAGAAACGGTCATTGCCGAGAAGTTCCAGGCAATGGTGAT
GCTGGGGCGAGTAAACAGCCGTATGAAGGATTTCTACGACATCTGGATCCTCAGCAGGTCTTTCGACTTCGGCGATGATC
GGCTGGCGCGCGCAATAGCCGCTACCTTTGATCGCCGCGAGACATCGATCCCCATTGACCTCCCCGACGCCCTAACGGAC
GCCTTTGCCAAGGACCAGCAAAAGCAGCGGCAATGGCGAGCTTTCGTTGAAGGCGTTGCACACAATCCTGGCGATCTGAC
AGACGTCATCGCGGAGATTGCCACATTCCTGATGCCGCACGCGGTTGCGGCTGCGAGGCTGGACGAATGA
Antitoxin
Download Length: 356 a.a. Molecular weight: 40672.70 Da Isoelectric Point: 5.6927
>AT162178 WP_000634203.1 NZ_CP055259:2843623-2844690 [Escherichia coli]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC
Download Length: 1068 bp
>AT162178 NZ_CP071635:c266201-265584 [Rhizobium sp. NZLR1]
ATGCCCGGTTCCGTCACGCAACGCCAGATCGCCCGAACCGTGCTAACTGAGCGCGGAATAGCACGTTTGGTGGAACTGCG
GAACGCAGGTGTGACGGCTGCCACCATGAGCCGAATGGAACGAGATGGTGAAGTGCTCCGGCTTGCCCGCGGTCTTTATC
AACTTCCTGATGCGCAGCTCGACGTCAACCACAGCCTGGCGGAGGTTGCCAAACGCGCACCCAAAGGCGTTATCTGCCTC
GTTTCGGCACTGGCGTTCCACGGCCTGACAGATCAGCTCCCAGGACAAATCTGGCTTGCCATAGGCCGTAAGGACTGGGC
TCCGAAACTGGACGGCCCCGCTATGCGCATCGTGCGTTTCACAGACGGCCTTCTCAACGAAAGCGTCGAACCCCATGTCA
TTGAAGGCGTTCCCGTGAGGGTCTTTGGAATTGCCAAGACAATTGCCGATTGCTTTCGCTATCGCAACAAGATCGGCCTT
TCGGTAGCGATAGAAGGGCTGCAGGAGGCGCTGCGGCAACGAAGGGCTACTCCTGGCGAAATCGCCAACCAGGCCGAACG
CGGTGGCGTCGGATCGGTGATCCGGCCGTATCTCGAGGCGCTGACCGCCAATGGCTAA
ATGCCCGGTTCCGTCACGCAACGCCAGATCGCCCGAACCGTGCTAACTGAGCGCGGAATAGCACGTTTGGTGGAACTGCG
GAACGCAGGTGTGACGGCTGCCACCATGAGCCGAATGGAACGAGATGGTGAAGTGCTCCGGCTTGCCCGCGGTCTTTATC
AACTTCCTGATGCGCAGCTCGACGTCAACCACAGCCTGGCGGAGGTTGCCAAACGCGCACCCAAAGGCGTTATCTGCCTC
GTTTCGGCACTGGCGTTCCACGGCCTGACAGATCAGCTCCCAGGACAAATCTGGCTTGCCATAGGCCGTAAGGACTGGGC
TCCGAAACTGGACGGCCCCGCTATGCGCATCGTGCGTTTCACAGACGGCCTTCTCAACGAAAGCGTCGAACCCCATGTCA
TTGAAGGCGTTCCCGTGAGGGTCTTTGGAATTGCCAAGACAATTGCCGATTGCTTTCGCTATCGCAACAAGATCGGCCTT
TCGGTAGCGATAGAAGGGCTGCAGGAGGCGCTGCGGCAACGAAGGGCTACTCCTGGCGAAATCGCCAACCAGGCCGAACG
CGGTGGCGTCGGATCGGTGATCCGGCCGTATCTCGAGGCGCTGACCGCCAATGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9J2A7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9J2B9 |