Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4496984..4497579 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HUU84_RS21650 Protein ID WP_000239579.1
Coordinates 4496984..4497334 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUU84_RS21655 Protein ID WP_001223208.1
Coordinates 4497328..4497579 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS21630 4492430..4493452 - 1023 WP_001368084.1 ABC transporter permease -
HUU84_RS21635 4493466..4494968 - 1503 WP_000210554.1 sugar ABC transporter ATP-binding protein -
HUU84_RS21640 4495108..4496064 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUU84_RS21645 4496374..4496904 + 531 WP_000055075.1 inorganic diphosphatase -
HUU84_RS21650 4496984..4497334 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HUU84_RS21655 4497328..4497579 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUU84_RS21660 4497791..4498132 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUU84_RS21665 4498135..4501914 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T162156 WP_000239579.1 NZ_CP055256:c4497334-4496984 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T162156 NZ_CP071623:240769-241191 [Rhizobium bangladeshense]
GTGAGACTTCTGCTGGACACCAACGTCCTGTCTGAGGTCACGAAGCCGAACCCCGATGTGCGCGTCCTGGGGTGGCTGGG
TGGGCTCGACGAGGATCTCTCCTTCATCAGCGTCGTGTCGGTCGCGGAAATCCGGCGCGGTGTCACCCTGATGGACAATG
GACGAAAACGTGACGTGCTGGCCGATTGGCTTGCCCGCGATCTGCCGCAGCGTTTCGAGCGGCGCATCATCCCAGTGGAC
GAAGCGGTGGCCCTGGCTTGGGGAGATCTGATGGGCCACGCAAAGCGGAACGGCCGCGGCCTTTCGTCGATGGATGGCCT
GATCGCCGCGACCGCGATTGCTCACGATCTCACCCTTGCGACGCGCAACACCAGGGATTTCGAAGGTTTTGGGATCGAGC
TCGTCGATCCATGGGTCGGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT162156 WP_001223208.1 NZ_CP055256:c4497579-4497328 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT162156 NZ_CP071623:240506-240772 [Rhizobium bangladeshense]
ATGCAGTCATCACGGCAAGGCGACGAAAGCTGGACCGTCGCCAGCGCAAAGGCGAAGCTTTCCGAAGTGATTGAACGCGC
GCAATCCGCGCCGCAGACTATTACACGCAACGGCAAGCCGAGCGTGGTCGTCGTCTCTGCGGAGGAATGGCAACGGAAGA
TCGCCCGCAAGGGGACGCTGGCCGAATTTCTGATGGAGTCACCGCTGCGTGGAGCCGATCTGGATCTCGAGCGTCAACGC
GACGAACCGCGCGATAGCGGACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References