Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4384084..4384910 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HUU84_RS21125 Protein ID WP_000854683.1
Coordinates 4384084..4384458 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUU84_RS21130 Protein ID WP_024186744.1
Coordinates 4384548..4384910 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS21095 4379343..4379756 + 414 WP_001368082.1 hypothetical protein -
HUU84_RS21100 4379753..4381222 + 1470 WP_001022619.1 serine/threonine protein kinase -
HUU84_RS21105 4381423..4382688 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
HUU84_RS21110 4383150..4383302 - 153 WP_001555250.1 hypothetical protein -
HUU84_RS21115 4383387..4383584 - 198 WP_001767903.1 DUF957 domain-containing protein -
HUU84_RS21120 4383596..4384087 - 492 WP_000976831.1 hypothetical protein -
HUU84_RS21125 4384084..4384458 - 375 WP_000854683.1 TA system toxin CbtA family protein Toxin
HUU84_RS21130 4384548..4384910 - 363 WP_024186744.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUU84_RS21135 4384989..4385210 - 222 WP_000692312.1 DUF987 domain-containing protein -
HUU84_RS21140 4385279..4385755 - 477 WP_072748601.1 RadC family protein -
HUU84_RS21145 4385771..4386256 - 486 WP_000206667.1 antirestriction protein -
HUU84_RS21150 4386348..4387166 - 819 WP_072748600.1 DUF945 domain-containing protein -
HUU84_RS21155 4387506..4388576 - 1071 WP_072748599.1 patatin-like phospholipase family protein -
HUU84_RS21160 4388573..4389478 - 906 WP_000203561.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(16-115)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13993.03 Da        Isoelectric Point: 8.2905

>T162155 WP_000854683.1 NZ_CP055256:c4384458-4384084 [Escherichia coli]
MKTLPDTHIREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTQFADERVIELHIEAGISLCDAVNFLVEKYALVRTGQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T162155 NZ_CP071622:c166680-166426 [Rhizobium bangladeshense]
ATGAACAGCAAGCAGAGAAAGACTCTCGCGGCGGTCTTCAAGGACCCGGTCTCGGGAACCATTGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGAGCCGACCTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGGGATCATTG
CGAGCTTCCATAGACCACATCCGGACAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13354.17 Da        Isoelectric Point: 6.6247

>AT162155 WP_024186744.1 NZ_CP055256:c4384910-4384548 [Escherichia coli]
VSDTLPGTTHPDNNRPWWGLPCTVMPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGEL
NPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 363 bp

>AT162155 NZ_CP071622:c166429-166073 [Rhizobium bangladeshense]
ATGAACATCATGACCTACAACGGATATCACGCTCGCATCGAGTTCGACGCTGAGGACGATGTGTTTTTCGGCAGGATTGC
AGGTATCTCGGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTTCATGAGGCAGTCGATGACT
ACCTGGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTGAATCAGTGGGCAGAAGAGGTGCTGGAAGAGGC
CGCCGACCATTATGCCGAGGCGCGCCTGCCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References