Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3739074..3739692 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUU84_RS18110 Protein ID WP_001291435.1
Coordinates 3739474..3739692 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag HUU84_RS18105 Protein ID WP_000344794.1
Coordinates 3739074..3739448 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS18095 3734163..3735356 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUU84_RS18100 3735379..3738528 + 3150 WP_001132470.1 multidrug efflux RND transporter permease subunit -
HUU84_RS18105 3739074..3739448 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
HUU84_RS18110 3739474..3739692 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HUU84_RS18115 3739863..3740414 + 552 WP_000102564.1 maltose O-acetyltransferase -
HUU84_RS18120 3740530..3741000 + 471 WP_000136192.1 YlaC family protein -
HUU84_RS18125 3741164..3742714 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUU84_RS18130 3742756..3743109 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HUU84_RS18140 3743488..3743799 + 312 WP_000409911.1 MGMT family protein -
HUU84_RS18145 3743830..3744402 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162152 WP_001291435.1 NZ_CP055256:3739474-3739692 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162152 NZ_CP071619:516365-516640 [Rhizobium bangladeshense]
ATGGAAGTCAAATGGACGCGCAAAGCGGTCTCGGACATTGCCCGCCTATATGACTTTCTCTCCCCTGTCGACCGGCGGGC
TGCGGCCCGTACCGTGCAGGCGCTGACGGCCGCGCCTGCTCGTTTGATGGAGCAGCCGCGTCTCGGCGAGCGGCTCGAGG
AGTTCGATCCCCGTGAGGTTCGCCGAATTCTCGTCGGCCGTTATGAGCTGCGCTACGAAATCCAGCAGTCGACAATCTAT
GTATTGCGGCTTTGGCATACGCGTGAGGATCGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT162152 WP_000344794.1 NZ_CP055256:3739074-3739448 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT162152 NZ_CP071619:516105-516365 [Rhizobium bangladeshense]
ATGGAGACCAAAGTTCTCACCGCTCATGTTCCGCTGCCGCTTGCGCAGAAGGTCGATCAACTCGCAATGCGGCTCGAGCG
TTCGCGCGGCTGGATCGTCAAGCAGGCCCTGACTGCATGGATTGATCAGGAAGAGGAGCGCCGGCGTTTGACACTTGAGG
CGCTGGCCGACGTGGATGGCGGCAACATTGTCGATCATCAGTCTGTTCAAGCGTGGGCAGACAGTCTTGATAGTGACGAG
CCGATTTCGTTGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References