Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3075778..3076612 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag HUU84_RS15075 Protein ID WP_000854808.1
Coordinates 3075778..3076155 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag HUU84_RS15080 Protein ID WP_001354276.1
Coordinates 3076244..3076612 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS15035 3070785..3071276 - 492 WP_001297187.1 DUF1097 domain-containing protein -
HUU84_RS15040 3071378..3071932 - 555 WP_001001902.1 molecular chaperone YcdY -
HUU84_RS15045 3071956..3072693 - 738 WP_000283664.1 zinc-binding phosphatase -
HUU84_RS15050 3072748..3073686 - 939 WP_001609861.1 glyoxylate/hydroxypyruvate reductase GhrA -
HUU84_RS15060 3074157..3074999 - 843 WP_063101836.1 DUF4942 domain-containing protein -
HUU84_RS15065 3075084..3075281 - 198 WP_029396577.1 DUF957 domain-containing protein -
HUU84_RS15070 3075293..3075781 - 489 WP_039022338.1 hypothetical protein -
HUU84_RS15075 3075778..3076155 - 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
HUU84_RS15080 3076244..3076612 - 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HUU84_RS15085 3076662..3077306 - 645 WP_029396485.1 hypothetical protein -
HUU84_RS15090 3077321..3077542 - 222 WP_000692353.1 DUF987 domain-containing protein -
HUU84_RS15095 3077611..3078087 - 477 WP_001384029.1 RadC family protein -
HUU84_RS15100 3078102..3078587 - 486 WP_000214317.1 antirestriction protein -
HUU84_RS15105 3078678..3079496 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T162151 WP_000854808.1 NZ_CP055256:c3076155-3075778 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T162151 NZ_CP071616:241830-242252 [Rhizobium bangladeshense]
GTGAGACTTCTGCTGGACACCAACGTCCTGTCTGAGGTCACGAAGCCGAACCCCGATGTGCGCGTCCTGGGGTGGCTGGG
TGGGCTCGACGAGGATCGCTCCTTCATCAGCGTCGTGTCGGTCGCAGAAATCCGGCGCGGTGTCACCCTGATGGACAATG
GACGAAAACGTGACGTGCTGGCCGATTGGCTTGCCCGCGATCTGCCGCAGCGTTTCGAGCGGCGCATCATCCCAGTGGAC
GAAGCGGTGGCCTTGGCTTGGGGAGATCTGATGGGCCACGCAAAGCGGAACGGCCGCGGCCTTTCGTCGATGGACGGCCT
GATCGCCGCGACCGCGATTGCTCACGATCTCACCCTTGCGACGCGCAACACCGGGGATTTCGAAGGTTTTGGGATCGAGC
TCGTCGATCCATGGGTCGGGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT162151 WP_001354276.1 NZ_CP055256:c3076612-3076244 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT162151 NZ_CP071616:241567-241833 [Rhizobium bangladeshense]
ATGCAGTCATCACGGCAAGGCGACGAAAGCTGGACCGTCGCCAGCGCAAAGGCGAAGCTTTCCGAAGTGATCGAACGCGC
GCAATCCGCGCCGCAGACTATTACACGCAACGGCAAGCCGAGCGTGGTCGTCGTCTCTGCGGAGGAATGGCAACGGAAGA
TCGCCCGCAAGGGGACGCTGGCCGAATTTCTGATGGAGTCACCGCTGCGTGGAGCCGATCTGGATCTCGAGCGTCAACGC
GACGAACCGCGCGATAGCGGATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References