Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2712947..2713585 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUU84_RS13255 Protein ID WP_000813794.1
Coordinates 2713409..2713585 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUU84_RS13250 Protein ID WP_001270285.1
Coordinates 2712947..2713363 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS13230 2708099..2709040 - 942 WP_001251313.1 ABC transporter permease -
HUU84_RS13235 2709041..2710054 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
HUU84_RS13240 2710072..2711217 - 1146 WP_000034363.1 ABC transporter substrate-binding protein -
HUU84_RS13245 2711462..2712868 - 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
HUU84_RS13250 2712947..2713363 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUU84_RS13255 2713409..2713585 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUU84_RS13260 2713807..2714037 + 231 WP_000494244.1 YncJ family protein -
HUU84_RS13265 2714129..2716090 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUU84_RS13270 2716163..2716699 - 537 WP_000429153.1 DNA-binding transcriptional regulator SutR -
HUU84_RS13275 2716752..2717966 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T162150 WP_000813794.1 NZ_CP055256:c2713585-2713409 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T162150 NZ_CP071615:c317648-317229 [Rhizobium bangladeshense]
ATGGCGCGTTACATGCTCGATACGAACATGTGTATCTACCTGATGAAAAACCAGCCGGAGCAGGTCGCTCGCCGCTTTGC
CAGTTGCTATGTGGGGGACGTGGTGATGTCCGCCATCACCTTCGCGGAACTCGGGTACGGTGTTTCCGCATCCGATGATC
CGGCACGAGAACTTGATAATCTCACCGCCCTGGCCGAGCTGATCACGGTAGAGCCGTTTGGGATCGCAGCAGCGCGTGCC
TACGGTCCGGTTCGAATGGCGACGAGAGACCGGAAGATAGATCATCTCGACAAACTGATCGCATCGCATGCGATCGCTCT
GGACACGGTATTGGTGACCAACAACACGCGGGACTTCCTGGCGCATCCCGGACTGAAGCTCGAAAACTGGCTGGACGCGG
AACGCAGAGAAACCAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT162150 WP_001270285.1 NZ_CP055256:c2713363-2712947 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT162150 NZ_CP071615:c317884-317648 [Rhizobium bangladeshense]
ATGCACACCACTAAAGCTTTCAAGAATGGAAATTCCCAGGCGGTTCGCATACCGGCGGAACTGGCGTTTGAGCGAACCGA
TGTTGAGTTGGAAATCGAGCGCATCGGCGACGAGCTTCGCATCCGTCCTGTGCATCGCTCCCTGGCCGGCGTTCTGGATG
TATTCGCCCGCTTCTCTCCGGATTTCATGCGCGACGGAAGAGAGTCCCATGAGCAAGAGGAGCGGGATAAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References