Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1382167..1382792 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HUU84_RS06760 Protein ID WP_000911329.1
Coordinates 1382394..1382792 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HUU84_RS06755 Protein ID WP_000450524.1
Coordinates 1382167..1382394 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS06730 1377969..1378439 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HUU84_RS06735 1378439..1379011 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HUU84_RS06740 1379157..1380035 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HUU84_RS06745 1380052..1381086 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
HUU84_RS06750 1381299..1382012 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HUU84_RS06755 1382167..1382394 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HUU84_RS06760 1382394..1382792 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HUU84_RS06765 1382939..1383802 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HUU84_RS06770 1383817..1385832 + 2016 WP_000829295.1 tRNA cytosine(34) acetyltransferase TmcA -
HUU84_RS06775 1385906..1386604 + 699 WP_000679823.1 esterase -
HUU84_RS06780 1386714..1386914 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T162138 WP_000911329.1 NZ_CP055256:1382394-1382792 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T162138 NZ_CP071602:c1364438-1364256 [Bordetella parapertussis]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT162138 WP_000450524.1 NZ_CP055256:1382167-1382394 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT162138 NZ_CP071602:c1364194-1363802 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References