Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 822652..823450 Replicon chromosome
Accession NZ_CP055256
Organism Escherichia coli strain AH25

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HUU84_RS04015 Protein ID WP_000854735.1
Coordinates 822652..823029 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HUU84_RS04020 Protein ID WP_032153712.1
Coordinates 823076..823450 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU84_RS03980 818215..819393 + 1179 WP_000094974.1 type II secretion system protein GspL -
HUU84_RS03985 819395..819931 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
HUU84_RS03990 820346..820672 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUU84_RS03995 820669..820932 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
HUU84_RS04000 821004..821870 - 867 WP_032153714.1 DUF4942 domain-containing protein -
HUU84_RS04005 821955..822152 - 198 WP_000839265.1 DUF957 domain-containing protein -
HUU84_RS04010 822164..822655 - 492 WP_023155722.1 hypothetical protein -
HUU84_RS04015 822652..823029 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HUU84_RS04020 823076..823450 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HUU84_RS04025 823530..823751 - 222 WP_000692345.1 DUF987 domain-containing protein -
HUU84_RS04030 823820..824296 - 477 WP_001186715.1 RadC family protein -
HUU84_RS04035 824312..824797 - 486 WP_032153711.1 antirestriction protein -
HUU84_RS04040 824889..825707 - 819 WP_001234693.1 DUF945 domain-containing protein -
HUU84_RS04045 825798..826007 - 210 WP_023155727.1 DUF905 family protein -
HUU84_RS04050 826037..826714 - 678 WP_023155728.1 hypothetical protein -
HUU84_RS04055 826833..827717 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / erm(B) / mph(A) papI / papB 820346..877060 56714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T162135 WP_000854735.1 NZ_CP055256:c823029-822652 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T162135 NZ_CP071594:c2907257-2907081 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT162135 WP_032153712.1 NZ_CP055256:c823450-823076 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT162135 NZ_CP071594:2906958-2907017 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References