Detailed information of TA system TA162097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2169749..2170845
• Replicon: chromosome
• Accession: NZ_CP055251
• Organism: Escherichia coli strain AH01

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8S7TJ53
• Locus tag: HUU83_RS10530
• Protein ID: WP_063112742.1
• Coordinates: 2170015..2170845 (+)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUU83_RS10525
• Protein ID: WP_001296726.1
• Coordinates: 2169749..2170015 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUU83_RS10525	2169749..2170015	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HUU83_RS10530	2170015..2170845	+	831	WP_063112742.1	HipA N-terminal domain-containing protein	Toxin
HUU83_RS10535	2171157..2171273	+	117	Protein_2054	helix-turn-helix transcriptional regulator	-
HUU83_RS10540	2171273..2171518	+	246	Protein_2055	fimbrial protein	-
HUU83_RS10545	2171878..2172588	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-
HUU83_RS10550	2172630..2175281	+	2652	WP_124783456.1	fimbrial biogenesis outer membrane usher protein	-
HUU83_RS10555	2175295..2175825	+	531	WP_000876784.1	type 1 fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2169749..2184502	14753

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (115-237)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 31181.99 Da
• Isoelectric Point: 10.0235

>T162097 WP_063112742.1 NZ_CP055251:2170015-2170845 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 831 bp

>T162097 NZ_CP071522:c3882875-3882477 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT162097 WP_001296726.1 NZ_CP055251:2169749-2170015 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT162097 NZ_CP071522:c3883171-3882878 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA