162074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3659950..3660570 Replicon chromosome
Accession NZ_CP055247
Organism Citrobacter freundii strain ZY198

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GTH18_RS17710 Protein ID WP_002892050.1
Coordinates 3660352..3660570 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GTH18_RS17705 Protein ID WP_003021733.1
Coordinates 3659950..3660324 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH18_RS17695 3655096..3656289 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GTH18_RS17700 3656312..3659461 + 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
GTH18_RS17705 3659950..3660324 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
GTH18_RS17710 3660352..3660570 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GTH18_RS17715 3660877..3661428 + 552 WP_032936967.1 maltose O-acetyltransferase -
GTH18_RS17720 3661545..3662015 + 471 WP_003021724.1 YlaC family protein -
GTH18_RS17725 3662094..3662234 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GTH18_RS17730 3662236..3662496 - 261 WP_003835926.1 type B 50S ribosomal protein L31 -
GTH18_RS17735 3662685..3664238 + 1554 WP_048241431.1 EAL domain-containing protein -
GTH18_RS17740 3664290..3664643 - 354 WP_003831033.1 DUF1428 family protein -
GTH18_RS17745 3664708..3665328 - 621 WP_048216756.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162074 WP_002892050.1 NZ_CP055247:3660352-3660570 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T162074 NZ_CP071521:2612242-2612349 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT162074 WP_003021733.1 NZ_CP055247:3659950-3660324 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT162074 NZ_CP071521:c2612192-2612129 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References