162064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1180366..1181085 Replicon chromosome
Accession NZ_CP055247
Organism Citrobacter freundii strain ZY198

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GTH18_RS05655 Protein ID WP_048217236.1
Coordinates 1180366..1180686 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GTH18_RS05660 Protein ID WP_048217237.1
Coordinates 1180720..1181085 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH18_RS05650 1176141..1179683 - 3543 WP_048217234.1 inverse autotransporter beta domain-containing protein -
GTH18_RS05655 1180366..1180686 - 321 WP_048217236.1 TA system toxin CbtA family protein Toxin
GTH18_RS05660 1180720..1181085 - 366 WP_048217237.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTH18_RS05665 1181117..1181338 - 222 WP_048217238.1 DUF987 domain-containing protein -
GTH18_RS05670 1181347..1181817 - 471 WP_048217239.1 DNA repair protein RadC -
GTH18_RS05675 1181887..1182708 - 822 WP_048217240.1 DUF945 domain-containing protein -
GTH18_RS05680 1182783..1183211 - 429 WP_048217241.1 hypothetical protein -
GTH18_RS05685 1183247..1183426 - 180 WP_048217242.1 hypothetical protein -
GTH18_RS05690 1183477..1184280 - 804 WP_048217243.1 hypothetical protein -
GTH18_RS05695 1184300..1184734 - 435 Protein_1114 hypothetical protein -
GTH18_RS05700 1185318..1185521 + 204 WP_156182980.1 inovirus-type Gp2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12037.62 Da        Isoelectric Point: 5.8789

>T162064 WP_048217236.1 NZ_CP055247:c1180686-1180366 [Citrobacter freundii]
MHISTVPATLPASSRLSPEQVWQQLLTYLLEHHYGLTLNDTPFHDDSTIQEHIEAGITLADAVNFLVERYELIRTDRKGI
TWQEQTPFLTATDILRAKKATGLVHT

Download         Length: 321 bp

>T162064 NZ_CP071521:c1119156-1118083 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13354.03 Da        Isoelectric Point: 6.4639

>AT162064 WP_048217237.1 NZ_CP055247:c1181085-1180720 [Citrobacter freundii]
MQSTTLSGSSAKNATCLQWGLKRNITPCFGARLVQEGNHLYFLADRAGFNGSFSDDEALSLDQAFPLMTKQLERMLTTGE
LDTRSQHCVTLHHNGLTCEADTLGSYGYVYIAIYPQSVVTR

Download         Length: 366 bp

>AT162064 NZ_CP071521:c1118090-1117719 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References