162063

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868833..869487 Replicon chromosome
Accession NZ_CP055247
Organism Citrobacter freundii strain ZY198

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag GTH18_RS04275 Protein ID WP_003026936.1
Coordinates 869080..869487 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag GTH18_RS04270 Protein ID WP_003026938.1
Coordinates 868833..869099 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH18_RS04245 864034..865467 - 1434 WP_048217186.1 6-phospho-beta-glucosidase BglA -
GTH18_RS04250 865588..866316 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
GTH18_RS04255 866369..866680 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
GTH18_RS04260 866843..867502 + 660 WP_003838267.1 hemolysin III family protein -
GTH18_RS04265 867596..868576 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
GTH18_RS04270 868833..869099 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
GTH18_RS04275 869080..869487 + 408 WP_003026936.1 protein YgfX Toxin
GTH18_RS04280 869532..870053 - 522 WP_003026933.1 flavodoxin FldB -
GTH18_RS04285 870167..871063 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
GTH18_RS04290 871087..871800 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GTH18_RS04295 871806..873539 + 1734 WP_032937435.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T162063 WP_003026936.1 NZ_CP055247:869080-869487 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T162063 NZ_CP071521:c1107621-1107292 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT162063 WP_003026938.1 NZ_CP055247:868833-869099 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162063 NZ_CP071521:c1107959-1107642 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References