Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1621649..1622261 Replicon chromosome
Accession NZ_CP055246
Organism Streptococcus pyogenes strain TSPY767

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag HVV27_RS08140 Protein ID WP_002988077.1
Coordinates 1621926..1622261 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag HVV27_RS08135 Protein ID WP_002988079.1
Coordinates 1621649..1621936 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV27_RS08110 (HVV27_08110) 1616838..1617821 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
HVV27_RS08115 (HVV27_08115) 1617825..1618754 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
HVV27_RS08120 (HVV27_08120) 1618802..1619317 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
HVV27_RS08125 (HVV27_08125) 1619352..1619780 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
HVV27_RS08130 (HVV27_08130) 1620226..1620999 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
HVV27_RS08135 (HVV27_08135) 1621649..1621936 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
HVV27_RS08140 (HVV27_08140) 1621926..1622261 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVV27_RS08145 (HVV27_08145) 1622400..1622576 + 177 Protein_1557 tyrosine-type recombinase/integrase -
HVV27_RS08150 (HVV27_08150) 1622707..1623099 - 393 WP_002982716.1 30S ribosomal protein S9 -
HVV27_RS08155 (HVV27_08155) 1623120..1623566 - 447 WP_002982710.1 50S ribosomal protein L13 -
HVV27_RS08160 (HVV27_08160) 1623784..1623990 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
HVV27_RS08165 (HVV27_08165) 1623987..1624685 - 699 WP_021299047.1 hypothetical protein -
HVV27_RS08170 (HVV27_08170) 1624821..1625681 - 861 WP_011529009.1 DegV family protein -
HVV27_RS08175 (HVV27_08175) 1625778..1626296 - 519 WP_011055010.1 NYN domain-containing protein -
HVV27_RS08180 (HVV27_08180) 1626300..1627046 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T162058 WP_002988077.1 NZ_CP055246:1621926-1622261 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T162058 NZ_CP071521:c606401-605937 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT162058 WP_002988079.1 NZ_CP055246:1621649-1621936 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT162058 NZ_CP071521:c606736-606401 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References