Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1896704..1897316 Replicon chromosome
Accession NZ_CP055227
Organism Erwinia amylovora strain Ea1189

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag GTU81_RS08775 Protein ID WP_012906750.1
Coordinates 1896704..1896883 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag GTU81_RS08780 Protein ID WP_004157632.1
Coordinates 1896906..1897316 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU81_RS08755 1892262..1893212 + 951 WP_004157624.1 DUF1471 domain-containing protein -
GTU81_RS08760 1893420..1894811 + 1392 WP_004157625.1 amino acid permease -
GTU81_RS08765 1894815..1895279 - 465 WP_004157626.1 hypothetical protein -
GTU81_RS08770 1895456..1896184 + 729 WP_004157629.1 two-component system response regulator RstA -
GTU81_RS08775 1896704..1896883 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
GTU81_RS08780 1896906..1897316 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTU81_RS08785 1897372..1898373 + 1002 WP_004157633.1 acyltransferase -
GTU81_RS08790 1899244..1899456 - 213 WP_004157635.1 hypothetical protein -
GTU81_RS08795 1899714..1899887 - 174 WP_004157636.1 hypothetical protein -
GTU81_RS08800 1899982..1900155 - 174 WP_013036045.1 hypothetical protein -
GTU81_RS08805 1900166..1900438 - 273 WP_004157637.1 hypothetical protein -
GTU81_RS08810 1901044..1901658 + 615 WP_004166850.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1887858..1910031 22173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T162048 WP_012906750.1 NZ_CP055227:1896704-1896883 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T162048 NZ_CP071505:795738-795944 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCGCTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCAACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT162048 WP_004157632.1 NZ_CP055227:1896906-1897316 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT162048 NZ_CP071505:795433-795726 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCAAACAAATTAAAATGAATTTAAAATCAAGACTAAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCTG
CATTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACATTTCAAAAATTAATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References