Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2209651..2210165 Replicon chromosome
Accession NZ_CP055225
Organism Staphylococcus aureus LAC

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HUW68_RS11045 Protein ID WP_000581792.1
Coordinates 2209651..2209860 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HUW68_RS11050 Protein ID WP_000138932.1
Coordinates 2209872..2210165 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW68_RS11025 2205159..2206517 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HUW68_RS11030 2206532..2207602 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HUW68_RS11035 2207920..2209122 + 1203 WP_001109939.1 rod shape-determining protein RodA -
HUW68_RS11040 2209386..2209523 - 138 WP_000828354.1 hypothetical protein -
HUW68_RS11045 2209651..2209860 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HUW68_RS11050 2209872..2210165 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HUW68_RS11055 2210331..2211815 + 1485 WP_000571549.1 cardiolipin synthase -
HUW68_RS11060 2211843..2212490 + 648 WP_001187629.1 HD domain-containing protein -
HUW68_RS11065 2213303..2214175 - 873 WP_000725802.1 membrane protein insertase YidC -
HUW68_RS11070 2214261..2214902 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T162036 WP_000581792.1 NZ_CP055225:c2209860-2209651 [Staphylococcus aureus LAC]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T162036 NZ_CP071491:c525778-525440 [Glaesserella parasuis]
ATGAATGTCGCTTTTGTGGAGTTGCCGCCTTTTGAGGAATATAGAAAAAAGTATCTTGACGATGACTCATTTAGATTATT
ACAAAATGAGTTACTAAAATTTCCCGATAAGGGAGAGCTTATTCAAGGTACTGGGGGACTAAGAAAATTGCGTATTGTGG
ATATTATTAGACAAAAAGGAAAAAGAGGCGGAGCTAGGGTAATCTATTACTATTACGTGCGAGGGAAACAAGTTTGGTTG
TTCCACGCCTACAATAAAAACCAACAAGACGATTTATCTAATGAAGAACTTGTGGTTTTGGCGAATACATTAAGCTATTT
AAAATCTTTAGTGAGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT162036 WP_000138932.1 NZ_CP055225:c2210165-2209872 [Staphylococcus aureus LAC]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT162036 NZ_CP071491:c525436-525128 [Glaesserella parasuis]
ATGGGAAAATTATTTAATGAACTAATGGAAGGGATGCAAGCATTAGAGTTACACTTACAAGGCAAAATTACACTAAAAAC
CACTGTTGTGGAAGTTCCTGATCCGATAGTGATTACCCCTGAAGAAGTGAAAGCTATTCGCCAAAAATTAAATCTTTCAC
AAGCGGTTTTTGCTCGTAAATTACACACTTCGGTGAGAACTTATCAAGGTTGGGAGCAAGGAAGAACAAAACCTAATCCA
CAAGCGGTTTTATTATTAAAAATGGTTGAAAAATCACCAAAAACATTTGAGCAGATTGCGAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References