Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2209651..2210165 Replicon chromosome
Accession NZ_CP055225
Organism Staphylococcus aureus LAC

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HUW68_RS11045 Protein ID WP_000581792.1
Coordinates 2209651..2209860 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HUW68_RS11050 Protein ID WP_000138932.1
Coordinates 2209872..2210165 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T162036 WP_000581792.1 NZ_CP055225:c2209860-2209651 [Staphylococcus aureus LAC]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T162036 NZ_CP071491:c525778-525440 [Glaesserella parasuis]
ATGAATGTCGCTTTTGTGGAGTTGCCGCCTTTTGAGGAATATAGAAAAAAGTATCTTGACGATGACTCATTTAGATTATT
ACAAAATGAGTTACTAAAATTTCCCGATAAGGGAGAGCTTATTCAAGGTACTGGGGGACTAAGAAAATTGCGTATTGTGG
ATATTATTAGACAAAAAGGAAAAAGAGGCGGAGCTAGGGTAATCTATTACTATTACGTGCGAGGGAAACAAGTTTGGTTG
TTCCACGCCTACAATAAAAACCAACAAGACGATTTATCTAATGAAGAACTTGTGGTTTTGGCGAATACATTAAGCTATTT
AAAATCTTTAGTGAGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT162036 WP_000138932.1 NZ_CP055225:c2210165-2209872 [Staphylococcus aureus LAC]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT162036 NZ_CP071491:c525436-525128 [Glaesserella parasuis]
ATGGGAAAATTATTTAATGAACTAATGGAAGGGATGCAAGCATTAGAGTTACACTTACAAGGCAAAATTACACTAAAAAC
CACTGTTGTGGAAGTTCCTGATCCGATAGTGATTACCCCTGAAGAAGTGAAAGCTATTCGCCAAAAATTAAATCTTTCAC
AAGCGGTTTTTGCTCGTAAATTACACACTTCGGTGAGAACTTATCAAGGTTGGGAGCAAGGAAGAACAAAACCTAATCCA
CAAGCGGTTTTATTATTAAAAATGGTTGAAAAATCACCAAAAACATTTGAGCAGATTGCGAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References