Detailed information of TA system TA162030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1989196..1989972
• Replicon: chromosome
• Accession: NZ_CP055225
• Organism: Staphylococcus aureus LAC

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: HUW68_RS09685
• Protein ID: WP_000031108.1
• Coordinates: 1989196..1989348 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: HUW68_RS09690
• Protein ID: WP_001251224.1
• Coordinates: 1989373..1989972 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW68_RS09670	1985159..1985980	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
HUW68_RS09675	1986443..1987828	-	1386	WP_000116224.1	class II fumarate hydratase	-
HUW68_RS09680	1988024..1988419	-	396	WP_000901021.1	hypothetical protein	-
HUW68_RS09685	1989196..1989348	-	153	WP_000031108.1	hypothetical protein	Toxin
HUW68_RS09690	1989373..1989972	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
HUW68_RS09695	1990131..1990601	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HUW68_RS09700	1990606..1991733	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
HUW68_RS09705	1991884..1992606	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
HUW68_RS09710	1992599..1994056	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T162030 WP_000031108.1 NZ_CP055225:c1989348-1989196 [Staphylococcus aureus LAC]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T162030 NZ_CP071490:c1309368-1309099 [Glaesserella parasuis]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGGCTAGTGCCGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT162030 WP_001251224.1 NZ_CP055225:c1989972-1989373 [Staphylococcus aureus LAC]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT162030 NZ_CP071490:c1309638-1309372 [Glaesserella parasuis]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAGACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAGAATGAGGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4