Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 884793..885270 Replicon chromosome
Accession NZ_CP055225
Organism Staphylococcus aureus LAC

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HUW68_RS04235 Protein ID WP_000052078.1
Coordinates 884793..884981 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HUW68_RS04240 Protein ID WP_001059690.1
Coordinates 885010..885270 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW68_RS04205 880834..881304 + 471 WP_000824472.1 hypothetical protein -
HUW68_RS04210 881645..882331 + 687 WP_001548082.1 thermonuclease family protein -
HUW68_RS04215 882688..882888 + 201 WP_001059082.1 cold-shock protein -
HUW68_RS04220 883384..883602 - 219 WP_000005886.1 hypothetical protein -
HUW68_RS04225 883664..883948 - 285 WP_001004395.1 hypothetical protein -
HUW68_RS04230 884036..884605 - 570 WP_001106654.1 hypothetical protein -
HUW68_RS04235 884793..884981 - 189 WP_000052078.1 hypothetical protein Toxin
HUW68_RS04240 885010..885270 - 261 WP_001059690.1 hypothetical protein Antitoxin
HUW68_RS04245 885611..885814 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HUW68_RS04250 885811..886047 - 237 WP_000368687.1 hypothetical protein -
HUW68_RS04255 886272..886853 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
HUW68_RS04260 886926..887543 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HUW68_RS04265 887698..888192 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HUW68_RS04270 888591..889013 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HUW68_RS04275 889161..889877 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T162027 WP_000052078.1 NZ_CP055225:c884981-884793 [Staphylococcus aureus LAC]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T162027 NZ_CP071490:679888-680172 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTATATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT162027 WP_001059690.1 NZ_CP055225:c885270-885010 [Staphylococcus aureus LAC]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT162027 NZ_CP071490:679637-679891 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACTGTTGCGAGTATTACAGAGCTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References