Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4801735..4802270 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name relE Uniprot ID Q6DB38
Locus tag HLB43_RS21325 Protein ID WP_011091708.1
Coordinates 4801983..4802270 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag HLB43_RS21320 Protein ID WP_010281712.1
Coordinates 4801735..4801986 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS21290 (HLB43_21280) 4797217..4797543 + 327 WP_039296540.1 helix-turn-helix domain-containing protein -
HLB43_RS21295 (HLB43_21285) 4797528..4797842 + 315 WP_039296542.1 HipA N-terminal domain-containing protein -
HLB43_RS21300 (HLB43_21290) 4797839..4798879 + 1041 WP_039296545.1 HipA domain-containing protein -
HLB43_RS21305 (HLB43_21295) 4798940..4799563 - 624 WP_039296550.1 LysE family translocator -
HLB43_RS21310 (HLB43_21300) 4799784..4800539 + 756 WP_039296553.1 thiol:disulfide interchange protein DsbG -
HLB43_RS21315 (HLB43_21305) 4800574..4801479 - 906 WP_039296557.1 siderophore-interacting protein -
HLB43_RS21320 (HLB43_21310) 4801735..4801986 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLB43_RS21325 (HLB43_21315) 4801983..4802270 + 288 WP_011091708.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLB43_RS21330 (HLB43_21320) 4802373..4803725 - 1353 WP_215216058.1 glutathione-disulfide reductase -
HLB43_RS21335 (HLB43_21325) 4803843..4804685 - 843 WP_215216059.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
HLB43_RS21340 (HLB43_21330) 4804991..4805284 + 294 WP_005968196.1 DUF2623 domain-containing protein -
HLB43_RS21345 (HLB43_21335) 4805295..4806116 - 822 WP_215216060.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11056.12 Da        Isoelectric Point: 10.3527

>T162025 WP_011091708.1 NZ_CP055224:4801983-4802270 [Pectobacterium atrosepticum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T162025 NZ_CP071489:c1859706-1859410 [Glaesserella parasuis]
ATGGCAGAAAAACACGGTTTACGTCCTTTTGATGTCGCTGAATTTTTGGATAACGAAGAAACAATACAAGCCTATTTAGC
AGAAGTATTAAAAGAGGGCGATCAAGATGAGTTTTTGGAAGCCCTTAATGATGTAGCAAGAGCAAGGGGGATCGCAGAAC
TTGCGAAGCAAACGGGGTTAGGTAGAGAAAGTTTATATAAAACCCTATCTAAAGGAAGTAAACCTCGTTTTGAAACTATT
CAAAAAATTTTAGGAGCATTTAATCTTGTGCTTATCCCACAAATAAAAAATAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT162025 WP_010281712.1 NZ_CP055224:4801735-4801986 [Pectobacterium atrosepticum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT162025 NZ_CP071489:c1860049-1859714 [Glaesserella parasuis]
ATGTCAGGAATTATCAACCAAATCATCATTACAGATAATTTTTCAAAGTGGCTAGATGGTTTAAAAAATCCTATTGCTAA
AGCAACAGTGGCAAGAAGAATTAAGAATACAGTAAAAGGTAATTTTGATGATCATAAAGCGCTTGCAGGTACTGGTGGAC
TTTATGAAATGCGAATAGCGACAGGCGCTGGTTATCGAATTTACTATGCACAGCAGGGCGATGTTATTTATATTCTGTTA
CAAGGTGGTGATAAATCAACACAGCAAGTCGATATTGAGAAAGCGAAAGCATTGTGGGCAGAATTAAAACAGACAGGAGG
AAGTAATGAATATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6DB38

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References