Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 3980947..3981472 | Replicon | chromosome |
| Accession | NZ_CP055224 | ||
| Organism | Pectobacterium atrosepticum strain Green1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HLB43_RS17590 | Protein ID | WP_039290137.1 |
| Coordinates | 3981188..3981472 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C6D956 |
| Locus tag | HLB43_RS17585 | Protein ID | WP_005973616.1 |
| Coordinates | 3980947..3981198 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLB43_RS17545 (HLB43_17540) | 3976527..3976787 | + | 261 | WP_039290147.1 | AlpA family transcriptional regulator | - |
| HLB43_RS17550 (HLB43_17545) | 3976784..3977008 | + | 225 | WP_039281995.1 | hypothetical protein | - |
| HLB43_RS17555 (HLB43_17550) | 3977017..3977274 | + | 258 | WP_215216019.1 | ash family protein | - |
| HLB43_RS17560 (HLB43_17555) | 3977364..3977561 | + | 198 | WP_039294701.1 | host cell division inhibitor Icd-like protein | - |
| HLB43_RS17565 (HLB43_17560) | 3977554..3977748 | + | 195 | WP_039294697.1 | hypothetical protein | - |
| HLB43_RS17570 (HLB43_17565) | 3977745..3978011 | + | 267 | WP_039290145.1 | hypothetical protein | - |
| HLB43_RS17575 (HLB43_17570) | 3978008..3978349 | + | 342 | WP_039290142.1 | DUF5375 family protein | - |
| HLB43_RS17580 (HLB43_17575) | 3978360..3980687 | + | 2328 | WP_039290139.1 | phage/plasmid primase, P4 family | - |
| HLB43_RS17585 (HLB43_17580) | 3980947..3981198 | + | 252 | WP_005973616.1 | prevent-host-death protein | Antitoxin |
| HLB43_RS17590 (HLB43_17585) | 3981188..3981472 | + | 285 | WP_039290137.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HLB43_RS17595 (HLB43_17590) | 3981773..3982000 | - | 228 | WP_039290135.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| HLB43_RS17600 (HLB43_17595) | 3981984..3982529 | - | 546 | WP_039282029.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| HLB43_RS17605 (HLB43_17600) | 3982905..3983332 | + | 428 | Protein_3469 | primase-like DNA-binding domain-containing protein | - |
| HLB43_RS17610 (HLB43_17605) | 3983636..3983989 | + | 354 | WP_215216020.1 | hypothetical protein | - |
| HLB43_RS17615 (HLB43_17610) | 3984192..3984794 | + | 603 | WP_215216021.1 | transglycosylase domain-containing protein | - |
| HLB43_RS17620 (HLB43_17615) | 3985671..3986150 | + | 480 | WP_226302329.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | iutA | 3849398..4001227 | 151829 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10907.88 Da Isoelectric Point: 10.1988
>T162020 WP_039290137.1 NZ_CP055224:3981188-3981472 [Pectobacterium atrosepticum]
MSYKLEFEEHALKEFKKLGAPVRELFTKKLKAVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL
MSYKLEFEEHALKEFKKLGAPVRELFTKKLKAVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL
Download Length: 285 bp
>T162020 NZ_CP071489:c893641-893141 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9079.35 Da Isoelectric Point: 5.0807
>AT162020 WP_005973616.1 NZ_CP055224:3980947-3981198 [Pectobacterium atrosepticum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL
Download Length: 252 bp
>AT162020 NZ_CP071489:c893918-893631 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|