Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3583400..3584025 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name Hha Uniprot ID Q6D810
Locus tag HLB43_RS15895 Protein ID WP_011092758.1
Coordinates 3583822..3584025 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag HLB43_RS15890 Protein ID WP_010282247.1
Coordinates 3583400..3583768 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS15875 (HLB43_15870) 3579058..3582186 + 3129 WP_011092760.1 efflux RND transporter permease subunit -
HLB43_RS15880 (HLB43_15875) 3582392..3582640 + 249 WP_011092759.1 type B 50S ribosomal protein L31 -
HLB43_RS15885 (HLB43_15880) 3582658..3582801 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
HLB43_RS15890 (HLB43_15885) 3583400..3583768 + 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
HLB43_RS15895 (HLB43_15890) 3583822..3584025 + 204 WP_011092758.1 HHA domain-containing protein Toxin
HLB43_RS15905 (HLB43_15900) 3584769..3585089 + 321 WP_011092757.1 MGMT family protein -
HLB43_RS15910 (HLB43_15905) 3585109..3585690 - 582 WP_011092756.1 YbaY family lipoprotein -
HLB43_RS15915 (HLB43_15910) 3585903..3586766 + 864 WP_011092755.1 acyl-CoA thioesterase II -
HLB43_RS15920 (HLB43_15915) 3586884..3588170 - 1287 WP_039290645.1 ammonium transporter AmtB -
HLB43_RS15925 (HLB43_15920) 3588210..3588548 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8159.55 Da        Isoelectric Point: 8.9008

>T162019 WP_011092758.1 NZ_CP055224:3583822-3584025 [Pectobacterium atrosepticum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKIPTAVWRYVR

Download         Length: 204 bp

>T162019 NZ_CP071489:468708-468875 [Glaesserella parasuis]
ATGATAAAACTTCTCAAAAAGAACGGTTGGGAGCTAGATAGCATAGTCGGTAGCCACCACCACTTTGAGAAGAAAAATCA
AAAGGGAGCAGGCAAAGTGACTGTTCCCCACCCGAGAAAAGACTTAGGCTTTCTCGAAAAGAAAATCAGAAAACAAGCGG
GGCTGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT162019 WP_010282247.1 NZ_CP055224:3583400-3583768 [Pectobacterium atrosepticum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT162019 NZ_CP071489:468914-469321 [Glaesserella parasuis]
ATGTTATACCCACTCATTTTTGAACAAGTTTCCGACGGCTATGTCGTTGCTATCCCAGATATTGACGGCTGTTATTCTGC
TGGAGATACCCTAGAAGAAACTTATAGCAACGTAAAACAAGCTATAGCACTTCATCTCGAATCTGTCGTCAAAGATGGGG
GAGAAATTCCAACGCCTACCGCTATCGAAAACCACAAAAACGACCCTGATTTAGACGGTCATAACGTATTTTTCGGTGTG
GTTGATGTCGATTTATCCCACCTAATGGGCAAAGCAGAGAAAATCAACATCACCCTCCCTAGCTATCTCATCAAACGCAT
TGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAATCTTAA
CCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5XPH8

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References