Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 815495..816135 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5XQX5
Locus tag HLB43_RS03590 Protein ID WP_039310134.1
Coordinates 815719..816135 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q6D0W2
Locus tag HLB43_RS03585 Protein ID WP_011095187.1
Coordinates 815495..815722 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS03570 (HLB43_03570) 810578..811141 - 564 WP_011095190.1 single-stranded DNA-binding protein -
HLB43_RS03575 (HLB43_03575) 811387..814221 + 2835 WP_215216099.1 excinuclease ABC subunit UvrA -
HLB43_RS03580 (HLB43_03580) 814239..814658 + 420 WP_011095188.1 secondary thiamine-phosphate synthase enzyme YjbQ -
HLB43_RS03585 (HLB43_03585) 815495..815722 + 228 WP_011095187.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HLB43_RS03590 (HLB43_03590) 815719..816135 + 417 WP_039310134.1 type II toxin-antitoxin system VapC family toxin Toxin
HLB43_RS03595 (HLB43_03595) 816463..817017 - 555 WP_039310136.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
HLB43_RS03600 (HLB43_03600) 817027..818040 - 1014 WP_039310137.1 type I-F CRISPR-associated protein Csy3 -
HLB43_RS03605 (HLB43_03605) 818054..818986 - 933 WP_039310139.1 type I-F CRISPR-associated protein Csy2 -
HLB43_RS03610 (HLB43_03610) 818983..820314 - 1332 WP_039310142.1 type I-F CRISPR-associated protein Csy1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15201.90 Da        Isoelectric Point: 9.3444

>T162016 WP_039310134.1 NZ_CP055224:815719-816135 [Pectobacterium atrosepticum]
VSRLFMLDTNICSFIMREHPAAVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMLLVDAFCRRLDAILPWDSA
AVDATTKIKIALAAAGTPIGPNDTAIAGHAISVKAVLVTNNLREFERVPGLMLEDWVK

Download         Length: 417 bp

>T162016 NZ_CP071487:c1335279-1334914 [Glaesserella parasuis]
ATGGAAACAGAAGAATGTCTTACTTTTATTGAAACCAAAATCTTTGAAGAAGACCGAAAAGCATTGATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTGGAATCTCACGAATTAGGCGATTTTATTCAGAATACGGGTGGTTGCAAAAAAA
TTCGCTGGAAACTAGAAAGCAATAATAAGGGCAAGAGTGGCGGTGTTCGTGTTATTTATTATGTATGGAGTACTAAGGGT
AGAATTTACCTTATTACGATGTATAGCAAAAGTGAAAAAGATAATTTGAATGAAAAAGAAAAAGCGATAATGCGTACCGT
TGTAGCTAAATTAACAGGAGAAAATAATGGAAAAGAAATTATTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8894.05 Da        Isoelectric Point: 4.5216

>AT162016 WP_011095187.1 NZ_CP055224:815495-815722 [Pectobacterium atrosepticum]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEERADADFMTERQDVVEEGRFEL

Download         Length: 228 bp

>AT162016 NZ_CP071487:c1334933-1334637 [Glaesserella parasuis]
ATGGAAAAGAAATTATTTGATCGCCTTATTCAAGGTTTAGAAGAAATGGTCGCCATTGAAAAAGGCGAGATAGAAGTACC
ACCACATCGTATTCATATCCATAAAATCCCGAATGTTAAAGCGATTAGAACCCTGCATCAGATGAAACAAGCAGAATTTG
CTTCCCTTTTAGGGGTAAGCCAAAACCTTGTGCAGTCGTGGGAAATCGGCAGACGAACGCCAAATGGTGCGGCACGGAAA
TTGCTTGCGATTATTGAGCAACAGCCTAATCTTGTCCCTGTACTTCAGAATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5XQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0J5XN10

References